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. 2014 Dec 9;6(3):1666–1677. doi: 10.18632/oncotarget.2762

Figure 4. Hypoxia and JAG1 overexpression increases ligand ICD production.

Figure 4

Hypoxia induces full length JAG1 production and increases ICD (~16 kD) stability. Similarly, overexpression of JAG1 increases the expression of the ligand ICD band.