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. 1994 Apr 26;91(9):3589–3592. doi: 10.1073/pnas.91.9.3589

Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

T Watanabe 1, Y Yonemura 1, H Yonekura 1, Y Suzuki 1, H Miyashita 1, K Sugiyama 1, S Moriizumi 1, M Unno 1, O Tanaka 1, H Kondo 1, et al.
PMCID: PMC43625  PMID: 8170952

Abstract

We previously isolated from a rat regenerating islet cDNA library a gene named Reg, which is expressed in regenerating islets but is not expressed in normal islets. Here we examined the effect of rat Reg protein on pancreatic beta-cell replication using both 90% depancreatized rats and isolated islets. The depancreatized rats that received i.p. administration of recombinant rat Reg protein (1 mg/kg per day) for 2 months showed amelioration of the surgical diabetes, as evidenced by a significant decrease in blood glucose with an increased beta-cell mass in the residual pancreas. In isolated rat islets, Reg protein (18-180 nM: 0.3-3 micrograms/ml) significantly increased [3H]thymidine incorporation into the nuclei of beta cells. These results indicate that Reg protein is a growth factor for pancreatic beta cells and also suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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