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. 1975 Aug;56(2):319–330. doi: 10.1172/JCI108096

Chemotherapy of experimental streptococcal endocarditis. IV. Further observations on prophylaxis.

L L Pelletier Jr, D T Durack, R G Petersdorf
PMCID: PMC436590  PMID: 1150874

Abstract

The ability of antibiotics to prevent Streptococcus sanguis endocarditis was tested in rabbits. Only vancomycin or a combination of penicillin G plus streptomycin always prevented infection when administered as a single dose. A loading dose of 30 mg/kg of phenoxymethyl penicillin (penicillin V) followed by additional 7.5 mg/kg doses for 48 h proved to be the only successful prophylactic program that could be given orally to man. Cefazolin alone or with streptomycin in multiple doses was also an effective alternative to penicillin or penicillin derivatives. Erythromycin uniformly failed to protect animals from bacterial endocarditis but showed greater prophylactic efficacy when a low inoculum of streptococci was used.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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