Abstract
Since its introduction in 1984, laparoscopic ovarian drilling has evolved into a safe and effective surgical treatment for anovulatory, infertile women with polycystic ovary syndrome (PCOS), unresponsive to clomiphene citrate. It is as effective as gonadotropins in terms of pregnancy and live birth rates, but without the risks of ovarian hyperstimulation syndrome and multiple pregnancies. It improves ovarian responsiveness to successive ovulation induction agents. Its favorable reproductive and endocrinal effects are sustained long. Despite its advantages, its use in unselected cases of PCOS or for non-fertility indications is not prudent owing to the potential risks of iatrogenic adhesions and ovarian insufficiency.
Keywords: Clomiphene citrate resistance, laparoscopic ovarian drilling, polycystic ovary syndrome
INTRODUCTION
Polycystic ovary syndrome (PCOS), a common endocrine disorder affecting women in the reproductive age group, is a predominant cause of anovulatory infertility,[1] with a prevalence rate of 17-20% (Rotterdam diagnostic criteria).[2,3] Clomiphene citrate (CC), a selective estrogen receptor modulator, still remains the first line of treatment for ovulation induction (OI) in PCOS patients.[4,5,6,7,8] CC-resistance refers to the failure to ovulate with 150 mg of CC for at least 3 cycles, while CC-failure is defined as failure to conceive with CC despite successful regular ovulation for 6-9 cycles.[9] Since its inception in 1984, laparoscopic ovarian drilling (LOD) has evolved into a safe and effective surgical option for CC-resistant PCOS cases. It is as effective as gonadotropins in terms of clinical pregnancy rates and live birth rates with the obvious advantages of spontaneous mono-ovulation there by minimizing the need for intensive monitoring and eliminating the risks of ovarian hyperstimulation syndrome (OHSS) and multiple pregnancies.[4,9,10,11] However, there are concerns regarding the long-term effects on ovarian function, especially iatrogenic adhesions and decreased ovarian reserve (DOR), which may potentially jeopardize future fertility. Hence, this procedure should be employed rationally in selected CC-resistant cases for the sole purpose of correction of anovulatory infertility.
The aim of this review is to evaluate and summarize the current body of literature regarding the role of LOD in management of PCOS entailing its different pre, intra and postoperative aspects.
MATERIALS AND METHODS
A systematic search of Medline, PubMed, the Cochrane Library, the National Guideline Clearinghouse, and the Health Technology Assessment Database was performed from January 1, 1984 to December 31, 2013 using key words “PCOS,” “laparoscopic ovarian surgery,” “LOD,” “laparoscopic ovarian diathermy,” “laparoscopic ablative therapy” and “laparoscopic ovarian electrocautery.” Relevant evidence was identified and assessed for quality and suitability for inclusion in the following order — Systematic reviews, meta-analyses, guidelines, randomized controlled trials (RCTs), prospective cohort studies, observational studies, nonsystematic reviews, and case series.
Mechanism of action
The exact mechanism is yet to be elucidated. The most plausible one is the destruction of ovarian follicles and stroma resulting in a decrease in androgen and inhibin levels and a secondary rise in follicle-stimulating hormone (FSH) levels.[10,12,13,14] Production of inflammatory growth factors like insulin-like growth factor-1, in response to thermal injury, further potentiates the actions of FSH on folliculogenesis, while increased blood flow to the ovary provoked by surgery, facilitates increased delivery of gonadotropins.[12,14]
Indications
The main indication for LOD is CC-resistant PCOS - as a second-line therapy for anovulatory infertile PCOS cases; specifically, as an alternative to gonadotropins.[6,9,10,11,15] Royal College of Obstetricians and Gynecologists,[16] American College of Obstetricians and Gynecologists,[17] Society of Obstetricians and Gynecologists, Canada[8] and the recent PCOS consensus working group[4] — All recommend its use in highly selected cases, particularly in those with hypersecretion of luteinizing hormone (LH), normal body mass index, those needing laparoscopic assessment of the pelvis or who live too far away from the hospital for the intensive monitoring required during gonadotropin therapy. Despite its theoretical advantages, LOD is not superior to CC, neither as a first line therapy for OI[11,18] nor for CC-failure[19] or prior to in vitro fertilization (IVF).[11] A recent Cochrane systematic review of 9 RCTs and 16 trials concluded that there was no evidence of a significant difference in rates of clinical pregnancy (39.7 vs. 40.5%) or live birth (34 vs. 38%) in women with clomiphene-resistant PCOS undergoing LOD compared to other medical treatments.[20] This implies that LOD is a valid, but not the sole option for CC-resistant PCOS. The evidence for improvement in biochemical hyperandrogenism translating into comparable improvement in clinical hyperandrogenism is not clear; hence LOD should not be offered for non-fertility indications like amelioration of acne or hirsutism or for regularization of menstrual cycles.[21,22,23]
Surgical technique
Standardization of the surgical techniques is lacking. Reproductive outcomes are comparable with laser and diathermy.[24] Electrocautery, using an insulated unipolar needle electrode with a non-insulated distal end measuring 1-2 cm, is the most commonly used method, although few authors have reported similar ovulation and pregnancy rates with bipolar energy.[25,26] The number of punctures is empirically chosen depending on the ovarian size. In the original procedure, 3-8 diathermy punctures (each of 3 mm diameter and 2-4 mm depth) per ovary were applied, using power setting of 200-300 W for 2-4 s.[27] Most surgeons perform four punctures per ovary, each for 4 s at 40 W (rule of 4), delivering 640 J of energy per ovary (the lowest effective dose recommended).[28] Nevertheless, clinical response is dose-dependent, with higher ovulation and pregnancy rates observed by increasing dose of thermal energy up to 600 J/ovary, irrespective of ovarian volume.[29] Conversely, adjusting thermal dose based on ovarian volume (60 J/cc) has better reproductive outcomes with similar postoperative adhesion rates than fixed dose of 600 J/ovary.[30] Despite lack of convincing evidence and significant reduction in operative time, most gynecologists still perform bilateral over unilateral drilling.[20,31,32,33]
Different modifications of the classic needle electrode technique such as laparoscopic ovarian multi-needle intervention,[34] LOD using a monopolar hook electrode,[35] LOD using the harmonic scalpel[36,37] and office microlaparoscopic ovarian drilling are proposed.[38,39] Various transvaginal methods such as transvaginal hydrolaparoscopy (fertiloscopy)[40,41,42] and transvaginal sonography - guided ovarian interstitial laser treatment are also developed.[43,44] However, larger prospective studies are needed to validate the use, safety, efficacy and long-term effects of these alternate techniques.
Predictors of success
On an average, 20-30% of anovulatory PCOS women fail to respond to LOD; possibly due to inadequate destruction of ovarian stroma or inherent resistance of the ovaries. The rationality of increasing the number of punctures or thermal energy applied to improve response at the expense of increased risks of adhesions and premature ovarian failure (POF) is yet to be proved. Several prognostic factors are evaluated to predict successful outcomes,[45,46,47,48,49,50,51,52,53,54,55,56,57] knowledge of which may be useful in judicious patient selection thus avoiding unnecessary surgery [Table 1]. Some of these appear to play a consistent role like preoperative LH concentrations and duration of infertility. However, impact of other factors such as obesity, insulin resistance (IR), metabolic syndrome and hyperandrogenism on LOD outcomes is still disputable.
Table 1.
Reproductive outcomes and endocrinal changes after laparoscopic ovarian drilling
The clinical and endocrine response to LOD is governed by a dose-response relationship. Four punctures per ovary using a power setting of 30 W applied for 5 s/puncture (i.e., 600 J/ovary) are sufficient to produce optimal response (67% spontaneous ovulation and conception rates).[27] Reducing the thermal energy (<300 J/ovary) and/or number of punctures (2/ovary) reduces the chances of spontaneous ovulation and conception, while higher thermal doses (>1000 J/ovary) and/or number of punctures (≥7/ovary) causes extensive tissue destruction without additional improvement in outcomes. Table 2 depicts the spontaneous ovulation and pregnancy rates after various techniques of LOD, which have varied from 30-90% to 13-88% respectively, within 1-year of the procedure. LOD alone is usually effective in <50% of women.[4,62] In such cases, addition of CC and recombinant FSH (rFSH) may be considered after 3 and 6 months respectively. LOD also improves the sensitivity of the ovaries towards subsequent CC and FSH, especially in those who are less hyperandrogenic and less insulin-resistant.[46,50,71,72]
Table 2.
The overall miscarriage rate varies from 0% to 36.5%.[14,55,56] Significant reduction of miscarriage rates after LOD were observed by Amer et al (reduced from 54% to 17%).[22] However, Cochrane systematic review did not find any significant differences in the abortion rates between LOD and other medical treatments (7.3% vs. 6.6%).[20]
The improved reproductive outcomes stem from an favorable intra-ovarian and systemic endocrinal milieu after LOD — Decreased plasma LH and in its pulsations, increased FSH, decreased LH:FSH ratio, a temporary fall in inhibin B, increased sex hormone binding globulin and a constant fall in androgens, free androgen index and Ferriman-Gallwey score.[10,27,36,58,65,66,73] Moreover, these beneficial reproductive and endocrinal effects are observed to chronically persist.[12,14,22,74,75,76,77]
Improvement in hormonal profiles does not translate into a comparable improvement in insulin sensitivity or reduction in risk of gestational diabetes mellitus (GDM).[10,14,61,78] Although patients with metabolic syndrome should not be precluded from LOD, adjuvant therapy with insulin sensitizers should be considered.[61] Few studies have demonstrated no impact on metabolic parameters.[79,80,81] Although, lower ovulation and pregnancy rates are reported in obese PCOS compared to lean counterparts,[48,49,50,57] one prospective study contradicts this.[46] Hence, obesity should not be considered as a contraindication, although anesthetic and surgical risks are increased in obese women.[46] However, impact of LOD in PCOS associated with obesity, IR or metabolic syndrome needs further research for clarification.
Complications
One of the main shortcomings of LOD is iatrogenic adhesions due to bleeding from the ovarian surface or premature contact between the ovary and the bowel after cauterization. Adhesion rates ranged from 0 to 100%,[12,33,34,37,62,82,83,84,85,86] involving higher risks with laser,[12,82,85] probably owing to lesser thermal penetration (2-4 mm) by the cone-shaped lesions of laser drilling compared with cylinder-shaped lesions (8 mm) of monopolar electrocoagulation. Most studies reported mild to moderate adhesions which do not seem to affect pregnancy rates after LOD. Adhesion prevention strategies like liberal peritoneal lavage,[87] application of adhesion barriers like intercede[85] and performance of adhesiolysis at early second-look laparoscopy,[82] are not effective in preventing de novo adhesions or in improving pregnancy rates.[20] Ovary should be raised before application of energy and saline washed after the procedure to decrease the temperature thereby reducing the risk of injury.[56]
Another potential risk is POF, especially if the ovarian blood supply is damaged inadvertently or if large number of punctures are made, leading to excessive destruction of ovarian follicular pool or production of anti-ovarian antibodies.[4] Only one isolated case of ovarian atrophy following high-energy drilling (eight coagulation points at 400 W for 5 s) is reported.[88] When applied correctly, it does not appear to compromise the ovarian reserve. A prospective comparative study found that the extent of ovarian tissue damage was limited, ranging from 0.4% after four to 1% after eight coagulation punctures, each of 40 W for 5 s.[89] In fact, changes in ovarian reserve markers can be interpreted as normalization of ovarian function rather than a reduction of ovarian reserve.[73,90] Coagulation should not be done within 8-10 mm of the ovarian hilum.[86,88] Unilateral drilling,[33,73] use of the harmonic scalpel,[37] use of bipolar energy or <5 perforations with monopolar energy[15] are associated with lesser risk of adhesions and DOR but with equivalent reproductive outcomes.
Alternative strategies in clomiphene citrate-resistant polycystic ovary syndrome and comparison of efficacy with laparoscopic ovarian drilling
A comparison of the efficacy between LOD and other drugs for OI in CC-resistant PCOS is demonstrated in Table 3. LOD is equally efficacious to rFSH in terms of ovulation, pregnancy and live birth rates.[34,91,92,100,101] Although cumulative conception rates at 6 months are lower with LOD than gonadotropin, they even-out after 12 months.[21] However, 2 RCTs found that the adjuvant therapy with CC or gonadotropins was required to achieve equivalent pregnancy and live birth rates in patients remaining anovulatory 8-12 weeks after LOD or those who subsequently became anovulatory.[62,93]
Table 3.
Trials comparing metformin with LOD in CC-resistant PCOS have shown variable results.[61,78,94] with some favoring LOD,[94] some favoring metformin[78] and others reporting equal efficacy.[61,95] Some studies have demonstrated higher ovulation and pregnancy rates with LOD but better attenuation of IR as well as lower GDM rates in those who conceived with metformin.[70,78,94] Even combined treatment with metformin, and CC is equally efficacious as LOD.[68,96] Since such combined treatment restores regular menstruation and ovulation in 70% women, this may be considered as a stepwise approach, before resorting to surgery or gonadotropin administration in CC-resistant PCOS cases.[102,103] Similarly, reproductive outcomes of other medical treatments such as letrozole,[67,97] CC plus tamoxifen[98] and CC plus rosiglitazone[99] are comparable with LOD.
Laparoscopic ovarian drilling in clomiphene citrate-failure and as first-line therapy in polycystic ovary syndrome
Role of LOD in CC-failure or as first-line therapy in PCOS remains largely undetermined. Only one RCT, comparing the efficacy of LOD versus continuation of CC up to six further cycles in 176 CC-failure PCOS patients, observed similar improvement in cycle length, pregnancy, miscarriage and live birth rates.[19] When compared to CC as first-line therapy in PCOS, one comparative study found higher ovulation (90.9% vs. 68%) and pregnancy (63.6% vs. 28%) rates in the LOD group[60] while an RCT found no difference at 12 months.[18] Interestingly, when offered to women after CC-resistance/failure, LOD achieved a pregnancy rate 2 times higher than that resulting from LOD as a first-line therapy (55% vs. 27%).[18] This possibly suggests that LOD may be more effective in CC-resistant PCOS women than in women without previous knowledge of their response to CC. Currently, LOD is not recommended for CC-failure PCOS or as first-line therapy due to lack of its superiority over CC.[11]
Pregnancy outcomes after laparoscopic ovarian drilling
Multiple pregnancy rate varies from 0% to 10%, but is significantly lower than gonadotropins, thus making LOD an attractive option for CC-resistant PCOS.[20] No difference in the incidence of OHSS and miscarriage rates is seen between LOD and other medical treatments.[20] LOD does not seem to improve risk of GDM, and higher incidence of GDM and pregnancy-induced hypertension have been reported after LOD.[52,69,78,104]
Cost-effectiveness
Laparoscopic ovarian drilling is more cost-effective than gonadotropins as single-treatment results in several mono-ovulatory cycles thus allowing multiple attempts at conception whereas one course of gonadotropin therapy yields a single ovulatory cycle with the inherent need for intensive monitoring.[20,34,92,100,105,106] The higher incidence of multiple pregnancies incurs extra costs in those who conceive with FSH.[20,100]
What next after laparoscopic ovarian drilling failure?
Laparoscopic ovarian drilling failure is defined as failure to ovulate within 6-8 weeks, recurrence of anovulatory status after an initial response or failure to conceive despite regular ovulation for 12 months.[9] Since LOD improves responsiveness of the polycystic ovaries to subsequent OI agents, reintroduction of drug treatments (first CC and then gonadotrophins) and possibly IVF can be considered in those do not spontaneously become pregnant within 6 months after LOD once ovulation has been re-established or after 3 months when ovulation has not been detected.[15]
Re-drilling — should it be done?
The effectiveness of a second LOD, that is re-drilling in women with PCOS was investigated in a retrospective study comprising of 20 women who had undergone LOD 1-6 years prior.[107] Overall, ovulation and pregnancy rates were 60% and 53%, respectively, with better outcomes in LOD-sensitive than LOD-resistant cases (83 and 67% vs. 25 and 29%, respectively). However, there are concerns of adhesions and DOR, precluding the feasibility of a RCT to address this issue. Until then, repeated application of LOD should not be encouraged.[4]
CONCLUSION
Laparoscopic ovarian drilling is currently recommended as a safe, efficacious and cost-effective alternative to gonadotropins for OI in infertile, anovulatory, CC-resistant PCOS women without the risks of OHSS or multiple gestation. Monopolar diathermy is the most widely used technique, although no technique is superior. Restoration of regular ovulation and menstruation as well as reduction in androgen and LH levels persist long-term. The evidence on the improvement of insulin sensitivity, lipid and lipoprotein disturbances, acne and hirsutism, are not clear; hence it should not be used for such non-fertility indications. Although iatrogenic adhesion formation and DOR are potential complications, they are of little clinical significance and can be minimized by limiting the number of punctures and energy applied. A detailed knowledge of the clinical and hormonal profile of the patients may be useful in a careful selection of cases likely to respond to LOD. Since LOD improves ovarian responsiveness to CC and gonadotropins, these may be considered after LOD failure instead of repeat LOD, before proceeding to the last resort that is, IVF. Despite its advantages, LOD is neither the first-line therapy in PCOS nor the treatment of choice in CC-resistant PCOS owing to the advent of a multitude of safe and efficacious oral alternatives and wider acceptance of relatively safe low-dose step-up regimen of gonadotropin therapy. Rather, it should be reserved to well-chosen anovulatory CC-resistant PCOS cases — Those with young age, raised LH levels, exaggerated response to gonadotropins, noncompliance or nonfeasibility with frequent, intensive monitoring or needing laparoscopic assessment of the pelvis. Importantly, reproductive specialists should remember that it is only an alternative, not the ultimate in management of PCOS.
Footnotes
Source of Support: Nil.
Conflict of Interest: None declared.
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