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. 1976 Apr;57(4):1089–1092. doi: 10.1172/JCI108352

Inhibition of insulin degradation by nonsuppressible insulin-like activity.

G Burghen, W C Duckworth, A E Kitabchi, S S Solomon, P L Poffenbarger
PMCID: PMC436754  PMID: 947951

Abstract

Nonsuppressible insulin-like activity, provided by three sources, was evaluated for its effect on the proteolytic degradation of insulin utilizing insulin protease obtained from rat liver homogenate as well as liver cell membranes. All three preparations of nonsuppressible insulin-like activity were found to be competitive inhibitors of insulin degradation. In addition human plasma was fractionated yielding an acetone precipitate which was found to have nonsuppressible insulin-like activity and to be a competitive inhibitor of insulin protease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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