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. 1976 May;57(5):1213–1220. doi: 10.1172/JCI108389

The effect of hepatectomy on the synthesis of 25-hydroxyvitamin D3.

E B Olson Jr, J C Knutson, M H Bhattacharyya, H F DeLuca
PMCID: PMC436774  PMID: 1262467

Abstract

The metabolism of [3H]vitamin D3 in hepatectomized vitamin D-deficient rats has been studied. Hepatectomy drastically disrupts vitamin D3 metabolism as revealed by prolonged high levels of [3H] vitamin D3 in the plasma compartment even 12 h after dose in contrast to sham-operated controls. Some conversion of [3H] vitamin D3 to [3H]25-hydroxyvitamin D3 was detected in hepatectomized rats, but the amount was small in spite of the high circulating levels of [3H]vitamin D3. Since the liver initially takes up much of an administered dose in normal animals and the conversion of [3H]vitamin D3 to [3H]25-hydroxyvitamin D3 is small in hepatectomized rats in spite of high circulating [3H]-vitamin D3, it is concluded that the liver plays a major role in the metabolism of vitamin D3 to 25-hydroxy-vitamin D3.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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