Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1976 May;57(5):1386–1390. doi: 10.1172/JCI108407

Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia.

F Ciccimarra, F S Rosen, E Schneeberger, E Merler
PMCID: PMC436792  PMID: 1083397

Abstract

Four patients with common, variable agammaglobulinemia were preveiously reported to have normal numbers of circulating B lymphocytes which synthesized normal amounts of IgG in tissue culture but failed to secrete the newly synthesized IgG. The B lymphocytes of these patients fail to incorporate [3H]mannose and/or [3H]glucosamine into newly synthesized IgG, whereas such incorporation appears to occur just before IgG secretion in cultures of normal B lymphocytes.

Full text

PDF
1386

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Choi Y. S., Biggar W. D., Good R. A. Biosynthesis and secretion of immunoglobulins by peripheral-blood lymphocytes in severe hypogammaglobulinaemia. Lancet. 1972 May 27;1(7761):1149–1152. doi: 10.1016/s0140-6736(72)91374-8. [DOI] [PubMed] [Google Scholar]
  2. Cooper M. D., Lawton A. R., Bockman D. E. Agammaglobulinaemia with B lymphocytes. Specific defect of plasma-cell differentiation. Lancet. 1971 Oct 9;2(7728):791–794. doi: 10.1016/s0140-6736(71)92742-5. [DOI] [PubMed] [Google Scholar]
  3. Della Corte E., Parkhouse R. M. Biosynthesis of immunoglobulin A (IgA). Secretion and addition of carbohydrate to monomer and polymer forms of a mouse myeloma protein. Biochem J. 1973 Nov;136(3):589–596. doi: 10.1042/bj1360589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Douglas S. D., Goldberg L. S., Fudenberg H. H. Clinical, serologic and leukocyte function studies on patients with idiopathic "acquired" agammaglobulinemia and their families. Am J Med. 1970 Jan;48(1):48–53. doi: 10.1016/0002-9343(70)90097-5. [DOI] [PubMed] [Google Scholar]
  5. Edelman G. M., Cunningham B. A., Gall W. E., Gottlieb P. D., Rutishauser U., Waxdal M. J. The covalent structure of an entire gammaG immunoglobulin molecule. Proc Natl Acad Sci U S A. 1969 May;63(1):78–85. doi: 10.1073/pnas.63.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Geha R. S., Merler E. Human lymphocyte mitogenic factor: synthesis by sensitized thymus-derived lymphocytes, dependence of expression on the presence of antigen. Cell Immunol. 1974 Jan;10(1):86–104. doi: 10.1016/0008-8749(74)90154-3. [DOI] [PubMed] [Google Scholar]
  7. Geha R. S., Rosen F. S., Merler E. Identification and characterization of subpopulations of lymphocytes in human peripheral blood after fractionation on discontinuous gradients of albumin. The cellular defect in X-linked agammaglobulinemia. J Clin Invest. 1973 Jul;52(7):1726–1734. doi: 10.1172/JCI107354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Geha R. S., Schneeberger E., Merler E., Rosen F. S. Heterogeneity of "acquired" or common variable agammaglobulinemia. N Engl J Med. 1974 Jul 4;291(1):1–6. doi: 10.1056/NEJM197407042910101. [DOI] [PubMed] [Google Scholar]
  9. Geha R. S., Schneeberger E., Rosen F. S., Merler E. Interaction of human thymus-derived and non-thymus-derived lymphocytes in vitro. Induction of proliferation and antibody synthesis in B lymphocytes by a soluble factor released from antigen-stimulated T lymphocytes. J Exp Med. 1973 Nov 1;138(5):1230–1247. doi: 10.1084/jem.138.5.1230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Leloir L. F. Two decades of research on the biosynthesis of saccharides. Science. 1971 Jun 25;172(3990):1299–1303. doi: 10.1126/science.172.3990.1299. [DOI] [PubMed] [Google Scholar]
  11. Melchers F. Biosynthesis of the carbohydrate portion of immunoglobulins. Kinetics of synthesis and secretion of [3H] leucine-, [3H] galactose- and [3H] mannose-labelled myeloma protein by two plasma-cell tumours. Biochem J. 1970 Oct;119(4):765–772. doi: 10.1042/bj1190765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Preud'Homme J. L., Griscelli C., Seligmann M. Immunoglobulins on the surface of lymphocytes in fifty patients with primary immunodeficiency diseases. Clin Immunol Immunopathol. 1973 Jan;1(2):241–256. doi: 10.1016/0090-1229(73)90025-1. [DOI] [PubMed] [Google Scholar]
  13. SMILEY J. D., HORTON H. ISOLATION AND STUDY OF THE FUNCTION OF HUMAN GAMMA-2-GLOBULIN GLYCOPEPTIDE. Immunochemistry. 1965 Mar;47:61–66. [PubMed] [Google Scholar]
  14. Weber K., Osborn M. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem. 1969 Aug 25;244(16):4406–4412. [PubMed] [Google Scholar]
  15. Zagury D., Uhr J. W., Jamieson J. D., Palade G. E. Immunoglobulin synthesis and secretion. II. Radioautographic studies of sites of addition of carbohydrate moieties and intracellular transport. J Cell Biol. 1970 Jul;46(1):52–63. doi: 10.1083/jcb.46.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES