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Model showing sequential events leading to induction of immunosuppressive CD4+ CD25+ FoxP3+ regulatory T (Treg) cells in breast cancer by way of transforming growth factor-β/interleukin-2 (TGF-β/IL-2) signalling pathways involving extracellular signal-regulated kinase (ERK)/SMAD and Janus kinase/signal transducer and activator of transcription (JAK/STAT).
