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. 1983 Feb;71(2):314–321. doi: 10.1172/JCI110771

Z-DNA-specific antibodies in human systemic lupus erythematosus.

E M Lafer, R P Valle, A Möller, A Nordheim, P H Schur, A Rich, B D Stollar
PMCID: PMC436869  PMID: 6822666

Abstract

Naturally occurring antibodies to left-handed Z-DNA have been shown to be present in the sera of human patients with systemic lupus erythematosus (SLE). These antibodies are of two types. One type reacts with both denatured DNA and Z-DNA. The other type is specific for Z-DNA and remained in the serum after removal of the cross-reactive antibody by extensive absorption on a denatured DNA affinity column. The antibodies appear to be specific for SLE and do not appear frequently in other rheumatic diseases. The presence of the antibody in SLE is correlated with the clinical manifestations of the disease, in parallel with antibodies to native and denatured DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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