There are formatting errors in Table 3 in the PDF version of the article. Please see the correct Table 3 here.
Table 3. LOH and MSI status detected in metachronous or sporadic ESCC and EADC patients.
| SPORADIC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patient | D3S37273p24.1 | D5S21065p12 | D5S6235q11.2 | D8S11308p23.1 | D9S9429p21.3 | D9S1719p21.3 | D13S26013q13.1 | D13S26713q13.2 | D17S132317q21.31 | D17S132717q21.31 |
| ESCC | ||||||||||
| 01 | ● | ○ | ● | ● | ○ | ● | ● | Ø MSI | ● | ● |
| 02 | ○ | ○ | ● | Ø | ○ | Ø | Ø | ● | Ø | ○ |
| 03 | Ø MSI | Ø | ○ | Ø | ○ | Ø | ● | ● | ○ | ● |
| 04 | ● | Ø | ● | Ø | ● | Ø | ● | Ø | ● | Ø |
| 05 | ● | Ø | Ø | Ø | ● | ○ | Ø | ○ | Ø | Ø |
| 06 | ● | ○ | Ø | ○ | ○ | ● MSI | Ø | ● | ○ | ○ |
| 07 | ● | ● | Ø | ● | ● | ● | Ø | ● | Ø | ● |
| 08 | ● | Ø | ● | Ø | ● | ● | ● | ○ | ● | ● |
| 09 | ● | ● | ● | ● | ● MSI | Ø | ● | ● | ● | Ø |
| 10 | Ø | ● | ● | ● | ○ | ● | ● | ● | Ø | ○ |
| 11 | ● | ○ MSI | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ |
| 12 | ○ | ○ | Ø | ● | ● | ● | ● | Ø | ○ | Ø |
| 13 | ○ | ● | ● | ● | ○ | ● | Ø | ● | ○ | ○ |
| 14 | ○ | ○ | ○ | ○ | ○ | ○ | ● | Ø | ○ | ○ |
| 15 | ● | Ø | Ø | ○ | ● | ● | ● | ● | ○ | ● |
| EADC | ||||||||||
| 01 | ● | ● | ● | ○ MSI | ● MSI | ○ | ○ | ● | Ø | Ø |
| 02 | ○ | ○ | Ø | ● | ○ | Ø | Ø | ● | Ø | Ø |
| 03 | ○ | ○ | Ø | ● | ○ | ○ | Ø | ● | Ø | ○ |
| 04 | ● | Ø | ○ | ● | ○ | ○ | ○ | ● | Ø | ● |
| 05 | Ø | ● | Ø | ● | ○ | ● | Ø | ● | Ø | ● |
| 06 | ● MSI | Ø MSI | ○ MSI | Ø MSI | ○ | ○ MSI | ○ | ○ MSI | ○ MSI | ● |
| 07 | Ø | ● | ● | Ø | ● | ● | ● | ● | ● | ● |
| 08 | ○ | Ø | ○ | ● | ● | Ø | DEL | ○ | ○ | ● |
| 09 | Ø | ○ | ○ | Ø | ○ | ● | ○ | ○ | Ø | Ø |
| 10 | Ø | Ø | ○ | ● | ● | ● | ● | Ø | Ø | Ø |
| 11 | ● | ● | ● | ● | ● | Ø | ● | ● | ● | Ø |
| Pos/inf (%) | 13/20(65) | 8/17(47) | 10/18(56) | 13/18(72) | 12/26(46) | 12/19(63) | 13/18(72) | 15/21(71) | 6/15(40) | 10/17(59) |
| METACHRONOUS | ||||||||||
| Patient | D3S37273p24.1 | D5S21065p12 | D5S6235q11.2 | D8S11308p23.1 | D9S9429p21.3 | D9S1719p21.3 | D13S26013q13.1 | D13S26713q13 | D17S132317q21.31 | D17S132717q21.31 |
| ESCC | ||||||||||
| 01 | ● | ○ | ● | ● | ○ | ● | Ø | ● | Ø | Ø |
| 02 | ○ | Ø | ● | Ø MSI | Ø | ● | ○ | ● | ● | Ø |
| 03 | ● | ● | Ø | Ø | ● | ○ | Ø | ● | ○ | ○ |
| 04 | ● | ○ | Ø | ○ | ○ | Ø | Ø | ● | ○ | ○ |
| 05 | ○ | Ø | ● | ○ | ○ | Ø | ○ | Ø | ○ | ○ |
| 06 | Ø | ● | ● | Ø | ○ | ● | ● | ● | ○ | ● |
| 07 | ● | NA | NA | Ø MSI | ● | ● | ○ | NA | NA | Ø |
| 08 | ● | ○ | Ø | ○ | ○ | ● | ○ | Ø | ○ | ○ |
| 09 | ○ | ○ | ● | Ø | ○ | ● | Ø | Ø | Ø | Ø |
| 10 | ● | ○ | ● | Ø | ● | Ø | ○ | Ø | Ø | ○ |
| 11 | Ø | ● | ○ | ● | ○ | ○ | ● | ○ | ○ | ○ |
| 12 | ● | ● | ● | ○ | ● | ● | ● | Ø | Ø | Ø MSI |
| 13 | Ø | ● | ● | ● | ● | ● | ● | ● | ○ | Ø |
| 14 | ● | ○ | Ø | ○ | ● | ● | Ø | ○ | Ø | Ø |
| EADC | ||||||||||
| 01 | ○ | ● | ● | ○ | ● MSI | ○ | ● | Ø | Ø | Ø |
| 02 | ○ | Ø | ○ | ○ | ○ | Ø | Ø | ○ | Ø | ○ |
| 03 | ● | ● | ○ | Ø | ○ | ● | Ø | ● | Ø | ○ |
| 04 | Ø | Ø | Ø | ● | ○ | ● | ○ | ○ | ● | ○ |
| 05 | Ø | ● | ○ | ● | ● | ○ | ● | ● | Ø | Ø |
| 06 | Ø | ● | Ø | ○ | ○ | ○ | ○ | Ø | ○ | Ø |
| Pos/inf (%) | 9/14(64) | 9/15(60) | 9/13(69) | 5/13(38) | 8/19(42) | 11/16(69) | 6/13(46) | 8/12(67) | 2/10(20) | 1/10(10) |
| p-value | 1 | 0.50 | 0.48 | 0.07 | 1 | 1 | 0.26 | 1 | 0.4 | 0.018 |
(●) LOH positive; (○) LOH negative; (Ø) uninformative; MSI (positive to microsatellite instability); NA (not amplifiable); DEL: deletion. p-value was calculated using the two-tailed Fisher’s exact test.
Reference
- 1. Boldrin E, Rumiato E, Fassan M, Cappellesso R, Rugge M, Chiarion-Sileni V, et al. (2015) Genetic Features of Metachronous Esophageal Cancer Developed in Hodgkin’s Lymphoma or Breast Cancer Long-Term Survivors: An Exploratory Study. PLoS ONE 10(1): e0117070 doi:10.1371/journal.pone.0117070 [DOI] [PMC free article] [PubMed] [Google Scholar]
