Table 4.
Mitochondrial Oxidative Stress and Lipoprotein Size and Number in Men and Women with HIV infection of Stable HAART (adjusted for age, gender, nadir CD4, CD4, viral load, high blood pressure, diabetes, HOMA, smoking, and lipid lowering medications)
| Type of Particle | Mitochondrial Oxidative Stress and Function | ||
|---|---|---|---|
| 8-oxo-dG (BF) | Complex I (O.D.)/μg protein x 103) | Complex IV (O.D.)/μg protein x 103) | |
| HDL | |||
| Small HDL Particles (umol/L) | OR=0.99 (p=0.7) | β =−0.06 (p=0.89) | β =−0.3 (p=0.29) |
| Medium HDL Particles (umol/L) | OR=1.00 (p=0.95) | β =0.2 (p=0.61) | β =0.26 (p=0.32) |
| Large HDL Particles (umol/L) | OR=0.87 (p=0.04) | β =−0.29 (p=0.73) | β =−0.3 (p=0.59) |
| HDL Particles (umol/L) (total) | OR=0.97 (p=0.27) | β =0.06 (p=0.85) | β =−0.05 (p=0.83) |
| HDL Size (nm) | OR=0.41 (p=0.04) | β =−4.55 (p=0.4) | β =−2.4 (p=0.5) |
| LDL | |||
| Small LDL Particles (total) (nmol/L) | OR=1.00 (p=0.67) | β =−0.02 (p=0.01) | β =−0.01 (p=0.11) |
| Large LDL Particles (nmol/L) | OR=1.00 (p=0.48) | β =0 (p=0.69) | β =0 (p=0.5) |
| LDL Particles (nmol/L) (total) | OR=1.00 (p=0.71) | β =−0.02 (p=0.01) | β =−0.01 (p=0.02) |
| LDL Size (nm) | OR=0.84 (p=0.59) | β =4.32 (p=0.3) | β =−0.42 (p=0.88) |
| VLDL | |||
| Small VLDL Particles (nmol/L) | OR=1.00 (p=0.62) | β =−0.13 (p=0.17) | β =−0.05 (p=0.44) |
| Medium VLDL Particles (nmol/L) | OR=1.00 (p=0.89) | β =−0.03 (p=0.72) | β =0.02 (p=0.75) |
| Large VLDL & Chylomicrons Particles (nmol/L) | OR=1.04 (p=0.24) | β =0.14 (p=0.7) | β =0.12 (p=0.62) |
| VLDL & Chylomicrons Particles (nmol/L) (total) | OR=1.00 (p=1.0) | β =−0.04 (p=0.39) | β =0 (p=0.89) |
| VLDL Size (nm) | OR=1.04 (p=0.19) | β =0.51 (p=0.12) | β =0.31 (p=0.15) |