Quality of life index in autoimmune bullous dermatosis patients

Abstract

BACKGROUND

Autoimmune bullous dermatoses are complex diseases triggered by autoantibodies action against epidermal antigens or the dermoepidermal junction. Blisters and vesicles that evolve with erosion areas characterize them. Although rare, they present high morbidity, affecting the quality of life of patients.

OBJECTIVES

To assess the magnitude of autoimmune bullous dermatoses on life quality of patients treated in a public university service in countryside of Brazil.

METHODS

This cross-sectional study was based on an inquiry with autoimmune bullous dermatoses patients assisted at outpatient university referral service. Elements related to quality of life were evaluated by the Dermatology Life Quality Index, as well as clinical and demographic data.

RESULTS

The study evaluated 43 patients with pemphigus foliaceus, 32 with pemphigus vulgaris, 6 with bullous pemphigoid and 3 with dermatitis herpetiformis. The average age was 48 ± 16 years and 34 (40%) were female. The median score (p25-p75) of the Dermatology Life Quality Index was 16 (9-19), classified as "severe impairment" of life quality, in which the greater impact was related to symptoms and feelings, daily and leisure activities.

CONCLUSIONS

Autoimmune bullous dermatoses inflict severe impairment of quality of life for patients followed by a public outpatient clinic in the countryside of Brazil.

INTRODUCTION

Autoimmune bullous dermatoses (ABD) are complex diseases triggered by autoantibodies action against epidermal antigens or dermoepidermal junction. Their clinical severity varies from formes frustes, with spontaneous remission, to lethal forms refractory to treatment. They are characterized by vesicules and cutaneous blisters which evolve with erosion areas. The classification depends on the site of the blister in the epithelium, which may be subepidermal and intraepidermal, besides the pathological substrate (e.g. location of acantholysis).¹

The main ABD are pemphigus vulgaris (PV), pemphigus foliaceus (PF), bullous pemphigoid (BP) and dermatitis herpetiformis (DH), low incidence entities (1.9 - 4.3 cases for every 100,000 adults) of high morbidity, which significantly compromise the quality of life (QOL) of patients.^2-5

There are few reports in literature about the impact of clinical symptoms of ABD in the quality of life of patients, and these are frequently underestimated by clinicians. ⁶

The Dermatology Life Quality Index (DLQI), developed by Finlay and Khan in 1994, was the first tool of QOL evaluation related to dermatology. ⁷ It consists of ten items, which estimate disease influence regarding: symptoms and feelings, daily activities, leisure, work, school, personal relationships and treatment. It has already been translated and validated into Brazilian Portuguese and applied to several dermatoses (DLQI-BRA) (Chart 1).^8-11

CHART 1.

DLQI-BRA (Dermatology Life Quality Index). Items and dimensions evaluated by the validated construct for the Portuguese language

Items / Questions*	Latent dimensions
1. How much was your skin affected during last week due to itching, inflammation, pain or burning?	Symptoms and feelings
2. How much embarrassment or other kind of limitation was caused by your skin during last week?
3. How much did your skin interfere with your activities of shopping or rides, at home or public places, during last week?	Daily activities
4. Up to what point did your skin interfere with the clothes you normally use during last week?
5. How much did your skin affect one of your social or leisure activities last week?	Leisure
6. How hard was it for you to practice sports during last week?
7. Did your skin prevent you from working or studying during last week?**	Work and school
8. How problematic has your relationship become with your partner, close friends or relatives, because of your skin?	Relationships
9. Up to what point did your skin present difficulties for your sexual life last week?
10. Up to what point did your dermatological treatment present problems for you last week?	Treatment
DLQI, Dermatology Life Quality Index; *Admits as answers: 3 (too much), 2 (a lot), 1 (a little), 0 (nothing or irrelevant); **Accepts: 3 (too much) or 0 (nothing or irrelevant). In case of negative, it asks: Has your skin been a problem for you at work or at school? Accepting: 2 (a lot) or 0 (nothing or irrelevant).

The impressions as to the impact of the disease on the life of patients are fundamented by cultural and ethnic aspects, which justifies the evaluation of QOL in different population groups. There are few studies on QOL in ABD of Latin-American populations.

The goal of this work was to evaluate the impact of autoimmune bullous dermatoses on the QOL of patients treated in a university service in Botucatu-SP (Brazil).

METHODS

A cross-sectional study was conducted in which a survey was performed regarding the impact on QOL caused by ABDs through the DLQI-BRA questionnaire.⁸ ABD carrying patients were included and interviewed during their medical appointments at the bullous diseases outpatient clinic of School of Medicine - Unesp (Faculdade de Medicina - Unesp) (Botucatu-SP), between the months of February and December of 2012. The project was approved by the Research Ethics Committee of the institution (no. 4137/2012) and all patients signed the informed consent form before the interview.

Demographical, clinical and QOL related data were investigated. The total score of DLQI was computed from the sum of indexes of the ten items evaluated and interpreted as: no impairment on life quality (0-1) or with light (2-5), moderate (6-10), severe (11-20) or very severe (21-30) impairment. ⁷

Categorical data were represented by their absolute frequencies and percentages, and compared by the chi-square test. Continuous data were represented by averages and standard deviations, or median and interquartile range, and the groups had medians compared by the Kruskal-Wallis test. Normality was assessed by Lilliefors test and homoscedasticity by Levene's test. The internal consistency of the questionnaire was estimated by Cronbach's alpha coefficient. The behavior of scores of items was evaluated regarding the similarity by evaluating clusters (cluster analysis - between items linkage).¹²

An analysis of total scores and of independent dimensions was later performed according to subgroups: gender, age, literacy and duration of disease. Data was adjusted by the generalized linear model (ANCOVA) and all covariates included.

Results were tabulated with MS Excel 2003 and analyzed by IBM SPSS 20.0 software. Value of p < 0.05 was considered significant.

RESULTS

84 patients with bullous diseases were interviewed. There was no exclusion of patients, and all agreed to take part in the study.

The main clinical and demographical data are shown in table 1. Highlights are the greater frequency of pemphiguses, long duration of diseases and DLQI graded as "severe impairment of life quality".

TABLE 1.

Clinical and demographical data of interviewed patients with ABD

Variates		Results
N		84
Gender *	Male	50 (60)
	Female	34 (40)
Age (in years) **		48 (16)
Schooling
(in years) ***		3 (5-8)
Diagnosis *
Pemphigus foliaceus		43 (51)
Pemphigus vulgaris		32 (38)
Bullous pemphigoid		6 (7)
Dermatitis herpetiformis		3 (4)
Duration of disease ***		7 (4-10)
DLQI ***		16 (9-19)

^*N (%),

^**average (standard deviation);

^***median (p25-p75).

Cronbach's alpha coefficient resulted in 0.81, assuring internal consistency of the questionnaire.

The scores of the different dimensions evaluated by the DLQI questionnaire are laid out on figure 1. The greater impact on quality of life of items related to symptoms and feelings, daily activities and leisure stands out.

FIGURE 1.

Scores of DLQI-BRA items for patients with ABD

Clusters of items with behaviors of similar scores are shown in figure 2.

FIGURE 2.

Dendrogram using behavior of scores of items that compose DLQI

The medians (p25-p75) of total DLQI scores of patients with pemphigus vulgaris, pemphigus foliaceus or bullous pemphigoid / dermatitis herpetiformis did not significantly differ from each other (16 (10-19) x 17 (13-20) x 11 (5-20); p=0.34).

When evaluated in a multivariate manner (ANCOVA), higher total scores of DLQI were associated with female gender and shorter schooling (Table 2).

TABLE 2.

Multivariate analysis (ANCOVA) of total score of DLQI according to clinical-demographic variables

Variable		Coeficient β	p-value
Age		0.03	0.96
Diagnosis
	PV	1.00
	PF	0.70
	BP/DH	-2.40	0.63
Years of schooling		-0.56	0.02
Duration of disease		0.06	0.43
Female gender		3.35	0.03

p (model) < 0.05; p (interception) <0.01

DISCUSSION

ABDs are chronic diseases, rare, however with great impairment of QOL of patients. The symptoms, clinical forms and also the effects of treatment contribute for a greater morbidity.

ABDs present several clinical presentations with mucosal involvement, and/or a great extension of the tegument. Even though it presents a decreasing rate of mortality due to the development of adjuvant treatments of the disease, all ABD subtypes have a restrict prognosis, PV being the worst of them.¹³

The DLQI score was high (16), revealing that the impact of QOL is larger than other chronic dermatological diseases such as: urticaria (14), leprosy (11), psoriasis, (10), basal cell carcinoma (9), atopic dermatitis (8), among others.^9,14-17 Mayrshofer and colleagues also showed a higher DLQI score than other dermatoses in patients with PV. ¹⁸

The impact measured was greater in women and people with few years of schooling. Paradisi et al reported, likewise, greater QOL involvement in the female gender, showing that women express greater suffering and fragility regarding ABDs.¹⁹

Paradisi and colleagues emphasize that QOL depends on the treatment and collateral effects caused by it, concluding that most deaths occur from complications arising from the treatment employed, triggering low compliance with medical recommendations.²⁰ It also pointed out that multiple comorbidities influence negatively the QOL of patients, showing a more important relation in patients with bullous dermatoses associated with psychiatric disorders, which presented lower QOL scores compared to those without psychiatric diseases.

The limitations of this study are based mainly on the evaluation by a single university center and by little sample representation of patients with bullous pemphigoid or dermatitis herpetiformis. However, they did not prevent perceiving the global impact that the ABD inflict on QOL of patients and positioning them among dermatoses of greater morbidity, besides being the first Brazilian investigation about QOL regarding ABDs.

CONCLUSION

Autoimmune bullous diseases inflict severe impairment to the quality of life of patients from a public outpatient clinic in the countryside of Brazil. Early precise diagnosis and therapeutic intervention aim to reduce the impact of QOL inflicted by ABD.