Table 2b.

Univariable mixed effects logistic regression analysis with significant time interaction

Covariate	Level	Effect at 1 year: OR (95% CI)	Yearly Change: OR (95% CI)	Interaction p-value
Current CART Use	Never	Ref	1.80 (1.095, 2.95)	0.038
	Current	3.58 (1.21, 10.63)	1.0043 (0.90, 1.13)
	Past	4.73 (1.42, 15.76)	0.82 (0.58, 1.18)
Current CD4 < 200	>= 200	Ref	1.053 (0.939, 1.18)	0.043
	< 200	1.98 (0.989, 3.95)	0.77 (0.57, 1.030)
Height	66in (25th %-ile)	1.39 (1.087, 1.77)	0.919 (0.81, 1.045)	0.0024
	69in (50th %-ile)	Ref	1.048 (0.938, 1.17)
	71in (75th %-ile)	0.80 (0.68, 0.946)	1.14 (1.0021, 1.30)
HIV Duration	48mo (25th %-ile)	0.74 (0.55, 1.015)	1.26 (1.013, 1.56)	0.0079
	120mo (50th %-ile)	Ref	1.082 (0.944, 1.24)
	180mo (75th %-ile)	1.28 (0.988, 1.65)	0.953 (0.85, 1.075)
Depressive Symptoms at Study Entry	BDI-II 0-13	Ref	1.16 (1.0076, 1.34)	0.022
	BDI-II 14-19	3.36 (1.30, 8.70)	0.76 (0.56, 1.016)
	BDI-II 20-28	3.33 (1.36, 8.11)	1.0072 (0.79, 1.28)
	BDI-II 29-63	3.07 (0.975, 9.70)	0.81 (0.59, 1.103)

BDI-II, Beck Depression Inventory, Second Edition.

* Covariates with LRT p-value < 0.10. ~ Covariates not significant. Ref: reference level (OR=1)