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. 2014 Oct 28;64(4):1235–1248. doi: 10.2337/db14-1164

Figure 3.

Figure 3

Wnt5a ablation inhibits obesity-induced adipose tissue inflammation in mice. Wnt5a-KO mice and WT littermates (n = 4–7 per group) were fed standard chow or HFHS diet for 12 weeks. A: qRT-PCR analysis of the transcript levels of IL-6, TNF-α, and CCL2/MCP-1 in epididymal WAT. B: qRT-PCR analysis of the expression of various macrophage-specific transcripts in epididymal WAT. C: Quantification of the amount of CLS in epididymal WAT of HFHS-fed mice. At least 1,000 adipocytes per mouse were analyzed. Representative images of hematoxylin/eosin-stained histological sections are shown. *P < 0.05; #P < 0.001; $P < 0.01, KO vs. WT. ND, normal diet.