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. 2015 Mar 30;10(3):e0123614. doi: 10.1371/journal.pone.0123614

Correction: Characterization of the RelBbu Regulon in Borrelia burgdorferi Reveals Modulation of Glycerol Metabolism by (p)ppGpp

The PLOS ONE Staff
PMCID: PMC4379094  PMID: 25822173

There are formatting errors in Table 1. Please see the corrected Table 1 here:

Table 1. Modulated selected genes with annotated function in B. burgdorferi 297 Δrel Bbu during growth in vitro at 34°C a .

Exponential phase Stationary phase
Gene Description Mean expression(log2rel Bbu/WT]) P Mean expression(log2rel Bbu/WT]) P
Transcriptional regulators
BB0168 dnaK suppressor (dksA) 1.31 0.002 3.26 <0.001
BB0419 response regulatory protein (rrp-1) 1.42 0.001
BB0420 sensory transduction histidine kinase/response regulator (hk1) 2.65 0.001 2.39 <0.001
BB0712 RNA polymerase σ70 factor (rpoD) 1.05 0.013 2.19 <0.001
DNA synthesis/repair
BB0022 Holliday junction DNA helicase (ruvB) 2.58 <0.001
BB0344 DNA helicase (uvrD) 2.79 0.006
BB0438 DNA polymerase III, β subunit (dnaN) 2.41 0.006 1.56 <0.001
BB0552 DNA ligase (lig) 2.64 0.010
BB0579 DNA polymerase III, α subunit (dnaE) 4.95 0.001
BB0710 DNA primase (dnaG), authentic frameshift 1.26 <0.001 1.33 <0.001
BB0836 excinuclease ABC, B subunit (uvrB) 2.35 <0.001
BB0837 excinuclease ABC, A subunit (uvrA) 1.04 0.003
Cell division
BB0177 glucose inhibited division protein B (gidB) 3.81 0.007
BB0178 glucose inhibited division protein A (gidA) 3.07 0.005
BB0302 cell division protein (ftsW) 2.96 0.001
BB0781 GTP-binding protein (obg) 1.03 0.004 1.95 <0.001
BB0789 cell division protein (ftsH) 1.01 <0.001
Protein synthesis
BB0229 ribosomal protein L31 (rpmE) 1.54 <0.001
BB0251 leucyl-tRNA synthetase (leuS) 3.41 <0.001
BB0514 phenylalanyl-tRNA synthetase, β subunit (pheT) 1.63 0.009
BB0615 ribosomal protein S4 (rpsD) 2.87 <0.001
BB0691 translation elongation factor G (fus-2) 0.96 0.001
BB0778 ribosomal protein L21 (rplU) 1.51 0.002
BB0780 ribosomal protein L27 (rpmA) 1.03 <0.001
Motility/chemotaxis
BB0147 flagellar filament 41 kDa core protein (flaB) -1.31 0.001
BB0181 flagellar hook-associated protein (flgK) -1.14 0.010
BB0271 flagellar biosynthesis protein (flhA) 1.95 0.002
BB0578 methyl-accepting chemotaxis protein (mcp-1) 3.06 0.012
BB0668 flagellar filament outer layer protein (flaA) -1.13 <0.001
BB0670 purine-binding chemotaxis protein (cheW-3) 2.03 0.011
BB0775 flagellar hook-basal body complex protein (flhO) 1.03 <0.001
Cell envelope
BB0382d basic membrane protein B (bmpB) -1.02 0.012 -1.59 <0.001
BB0383 basic membrane protein A (bmpA) -1.15 0.016
BB0385 basic membrane protein D (bmpD) -2.93 0.007
BBA15 outer surface protein A (ospA) -1.81 0.001
BBA16 outer surface protein B (ospB) -1.54 0.002
BBA60 surface lipoprotein P27 -5.07 <0.001
BBA74 membrane-associated periplasmic protein -2.03 <0.001
BBB07 α3β1 integrin-binding protein 1.42 <0.001
BBJ41 antigen P35, putative -8.62 <0.001
BBM23 b holin (blyA) 1.74 <0.001 1.43 <0.001
BBN24 c holin (blyB) 2.99 <0.001 1.17 <0.001
Central metabolism/carbon source transporters
BB0240 glycerol uptake facilitator (glpF) -4.54 <0.001 -4.76 <0.001
BB0241 glycerol kinase (glpK) -8.27 <0.001 -5.47 <0.001
BB0243 glycerol-3-phosphate dehydrogenase (glpD) -6.52 <0.001 -3.79 <0.001
BB0328 oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-1) -1.16 0.001 -2.65 0.002
BB0329 oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-2) -1.33 <0.001
BB0330 oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-3) -4.07 0.015
BB0334 oligopeptide ABC transporter, ATP-binding protein (oppD) -3.25 0.006 -1.21 0.002
BB0335 oligopeptide ABC transporter, ATP-binding protein (oppF) -1.51 <0.001
BBB04 chitobiose transporter protein (chbC) 1.83 0.004 2.11 <0.001
BBB05 chitobiose transporter protein (chbA) 4.05 0.013 5.07 <0.001
BBB06 chitobiose transporter protein (chbB) 5.02 <0.001
BB0683 3-hydroxy-3-methylglutaryl-CoA synthase (hmgs) 1.23 0.010 1.65 <0.001
BB0685 3-hydroxy-3-methylglutaryl-CoA reductase (mvaA) 1.36 <0.001 4.39 <0.001

aTranscriptional analysis from microarrays (regular font) or RT-PCR (boldface). Where data from RT-PCR is shown, microarrays showed no significant difference in gene expression between B. burgdorferi 297 Δrel Bbu and wild type.

bExpression values for blyA orthologs BBM23, BBP23, BBR23 that showed increased expression in stationary phase and BBN23, BBR23 and BBS23 that showed increased expression in exponential phase were considered as a single transcript because they are 100% identical in sequence.

cExpression values for blyB orthologs BBN24, BBR24, BBS24 that showed increased expression in stationary phase and BBN24, BBR24, and BBS23 that showed increased expression in exponential phase were considered as a single transcript because they are 100% identical in sequence.

Reference


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