Correction: Characterization of the Rel_Bbu Regulon in Borrelia burgdorferi Reveals Modulation of Glycerol Metabolism by (p)ppGpp

There are formatting errors in Table 1. Please see the corrected Table 1 here:

Table 1. Modulated selected genes with annotated function in B. burgdorferi 297 Δrel _Bbu during growth in vitro at 34°C ^a .

		Exponential phase		Stationary phase
Gene	Description	Mean expression(log2 [Δrel Bbu/WT])	P	Mean expression(log2 [Δrel Bbu/WT])	P
Transcriptional regulators
BB0168	dnaK suppressor (dksA)	1.31	0.002	3.26	<0.001
BB0419	response regulatory protein (rrp-1)			1.42	0.001
BB0420	sensory transduction histidine kinase/response regulator (hk1)	2.65	0.001	2.39	<0.001
BB0712	RNA polymerase σ70 factor (rpoD)	1.05	0.013	2.19	<0.001
DNA synthesis/repair
BB0022	Holliday junction DNA helicase (ruvB)			2.58	<0.001
BB0344	DNA helicase (uvrD)			2.79	0.006
BB0438	DNA polymerase III, β subunit (dnaN)	2.41	0.006	1.56	<0.001
BB0552	DNA ligase (lig)			2.64	0.010
BB0579	DNA polymerase III, α subunit (dnaE)			4.95	0.001
BB0710	DNA primase (dnaG), authentic frameshift	1.26	<0.001	1.33	<0.001
BB0836	excinuclease ABC, B subunit (uvrB)			2.35	<0.001
BB0837	excinuclease ABC, A subunit (uvrA)			1.04	0.003
Cell division
BB0177	glucose inhibited division protein B (gidB)			3.81	0.007
BB0178	glucose inhibited division protein A (gidA)			3.07	0.005
BB0302	cell division protein (ftsW)			2.96	0.001
BB0781	GTP-binding protein (obg)	1.03	0.004	1.95	<0.001
BB0789	cell division protein (ftsH)			1.01	<0.001
Protein synthesis
BB0229	ribosomal protein L31 (rpmE)			1.54	<0.001
BB0251	leucyl-tRNA synthetase (leuS)			3.41	<0.001
BB0514	phenylalanyl-tRNA synthetase, β subunit (pheT)			1.63	0.009
BB0615	ribosomal protein S4 (rpsD)			2.87	<0.001
BB0691	translation elongation factor G (fus-2)			0.96	0.001
BB0778	ribosomal protein L21 (rplU)			1.51	0.002
BB0780	ribosomal protein L27 (rpmA)			1.03	<0.001
Motility/chemotaxis
BB0147	flagellar filament 41 kDa core protein (flaB)			-1.31	0.001
BB0181	flagellar hook-associated protein (flgK)			-1.14	0.010
BB0271	flagellar biosynthesis protein (flhA)			1.95	0.002
BB0578	methyl-accepting chemotaxis protein (mcp-1)			3.06	0.012
BB0668	flagellar filament outer layer protein (flaA)			-1.13	<0.001
BB0670	purine-binding chemotaxis protein (cheW-3)			2.03	0.011
BB0775	flagellar hook-basal body complex protein (flhO)			1.03	<0.001
Cell envelope
BB0382d	basic membrane protein B (bmpB)	-1.02	0.012	-1.59	<0.001
BB0383	basic membrane protein A (bmpA)			-1.15	0.016
BB0385	basic membrane protein D (bmpD)	-2.93	0.007
BBA15	outer surface protein A (ospA)			-1.81	0.001
BBA16	outer surface protein B (ospB)			-1.54	0.002
BBA60	surface lipoprotein P27			-5.07	<0.001
BBA74	membrane-associated periplasmic protein			-2.03	<0.001
BBB07	α3β1 integrin-binding protein	1.42	<0.001
BBJ41	antigen P35, putative			-8.62	<0.001
BBM23 b	holin (blyA)	1.74	<0.001	1.43	<0.001
BBN24 c	holin (blyB)	2.99	<0.001	1.17	<0.001
Central metabolism/carbon source transporters
BB0240	glycerol uptake facilitator (glpF)	-4.54	<0.001	-4.76	<0.001
BB0241	glycerol kinase (glpK)	-8.27	<0.001	-5.47	<0.001
BB0243	glycerol-3-phosphate dehydrogenase (glpD)	-6.52	<0.001	-3.79	<0.001
BB0328	oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-1)	-1.16	0.001	-2.65	0.002
BB0329	oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-2)			-1.33	<0.001
BB0330	oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-3)			-4.07	0.015
BB0334	oligopeptide ABC transporter, ATP-binding protein (oppD)	-3.25	0.006	-1.21	0.002
BB0335	oligopeptide ABC transporter, ATP-binding protein (oppF)			-1.51	<0.001
BBB04	chitobiose transporter protein (chbC)	1.83	0.004	2.11	<0.001
BBB05	chitobiose transporter protein (chbA)	4.05	0.013	5.07	<0.001
BBB06	chitobiose transporter protein (chbB)			5.02	<0.001
BB0683	3-hydroxy-3-methylglutaryl-CoA synthase (hmgs)	1.23	0.010	1.65	<0.001
BB0685	3-hydroxy-3-methylglutaryl-CoA reductase (mvaA)	1.36	<0.001	4.39	<0.001

^aTranscriptional analysis from microarrays (regular font) or RT-PCR (boldface). Where data from RT-PCR is shown, microarrays showed no significant difference in gene expression between B. burgdorferi 297 Δrel _Bbu and wild type.

^bExpression values for blyA orthologs BBM23, BBP23, BBR23 that showed increased expression in stationary phase and BBN23, BBR23 and BBS23 that showed increased expression in exponential phase were considered as a single transcript because they are 100% identical in sequence.

^cExpression values for blyB orthologs BBN24, BBR24, BBS24 that showed increased expression in stationary phase and BBN24, BBR24, and BBS23 that showed increased expression in exponential phase were considered as a single transcript because they are 100% identical in sequence.