Table 1.
All | Normal | MCI | P-value | |
---|---|---|---|---|
Men/Women (n) | 26/28 | 10/8 | 16/20 | 0.44 |
Age (years) | 65 ± 6 | 65 ± 6 | 66 ± 7 | 0.59 |
Education (years) | 16 ± 2 | 17 ± 2 | 16 ± 2 | 0.29 |
Height (cm) | 170 ± 8 | 171 ± 9 | 170 ± 8 | 0.64 |
Body mass (kg) | 80 ± 14 | 80 ± 16 | 80 ± 13 | 0.89 |
Body mass index (kg/m2) | 27 ± 4 | 27 ± 4 | 28 ± 4 | 0.50 |
Neurocognitive measures | ||||
Mini-Mental State Exam | 29 ± 1 | 29 ± 1 | 29 ± 1 | 0.46 |
CVLT Short Delay Free Recall | 10 ± 3 | 11 ± 2 | 9 ± 2 | <0.01 |
CVLT Long Delay Free Recall | 10 ± 3 | 12 ± 2 | 10 ± 3 | <0.01 |
Trail Making Test part A | 28 ± 10 | 29 ± 11 | 27 ± 9 | 0.80 |
Trail Making Test part B | 72 ± 25 | 62 ± 18 | 77 ± 26 | 0.01 |
Trail Making Test part B-A | 44 ± 21 | 33 ± 16 | 49 ± 21 | <0.01 |
Cardiovascular measures | ||||
Systolic BP (mmHg) | 124 ± 14 | 125 ± 14 | 124 ± 14 | 0.82 |
Diastolic BP (mmHg) | 74 ± 8 | 74 ± 9 | 74 ± 8 | 0.82 |
Heart rate (bpm) | 61 ± 10 | 63 ± 10 | 60 ± 11 | 0.34 |
Carotid-femoral PWV (m/sec) | 11.0 ± 2.7 | 11.2 ± 2.2 | 11.0 ± 2.9 | 0.54 |
BRS (ms/mmHg) | 4.99 ± 2.33 | 5.09 ± 2.80 | 4.94 ± 2.10 | 0.91 |
Brain volumetric measures | ||||
Total grey matter volume (%ICV) | 39.7 ± 2.4 | 40.3 ± 2.1 | 39.4 ± 2.6 | 0.23 |
Total white matter volume (%ICV) | 34.7 ± 3.1 | 34.7 ± 2.3 | 34.7 ± 3.5 | 0.83 |
Medial temporal lobe volume (%TB) | 1.62 ± 0.13 | 1.63 ± 0.13 | 1.62 ± 0.12 | 0.73 |
Hippocampus volume (%TB) | 0.69 ± 0.08 | 0.69 ± 0.06 | 0.69 ± 0.09 | 0.93 |
Total WMH volume (%ICV) | 0.27 ± 0.44 | 0.25 ± 0.39 | 0.29 ± 0.46 | 0.79 |
Bold: P-value<0.05 between normal vs. MCI subjects. Values are mean ± standard deviation. BP=blood pressure, BRS=baroreflex sensitivity, CVLT=California Verbal Learning Test, ICV=intracranial volume, MCI=mild cognitive impairment, PWV=pulse wave velocity, TB=total brain volume, and WMH=white matter hyperintensity. %ICV and %TB represent brain volume normalized to intracranial and total brain volumes respectively.