Table 3.

Multivariate adjusted relations of central artery stiffness and baroreflex sensitivity with microstructural tissue integrity of global and regional white matter fiber tracts, as assessed by radial diffusivity

White matter regions		Carotid-femoral PWV		Baroreflex sensitivity
		β ± SE	P-value	β ± SE	P-value
Global white matter		0.38 ± 0.12	<0.01	−0.39 ± 0.10	0.001
Corpus callosum	genu	0.32 ± 0.17	0.07	−0.24 ± 0.14	0.10
	body	0.31 ± 0.16	0.055	−0.12 ± 0.13	0.37
	splenium	0.36 ± 0.18	0.055	−0.39 ± 0.15	0.01
Corona radiata	anterior	0.30 ± 0.14	0.03	−0.30 ± 0.11	0.01
	superior	0.28 ± 0.15	0.07	−0.28 ± 0.13	0.04
	posterior	0.47 ± 0.15	<0.01	−0.32 ± 0.12	0.01
Internal capsule	anterior limb	0.18 ± 0.17	0.29	−0.16 ± 0.14	0.25
	posterior limb	0.24 ± 0.16	0.14	−0.04 ± 0.13	0.78
	retrolenticular part	0.37 ± 0.17	0.03	−0.28 ± 0.14	0.047
External capsule		0.29 ± 0.16	0.07	−0.24 ± 0.13	0.08
Superior longitudinal fasciculus		0.38 ± 0.17	0.04	−0.23 ± 0.15	0.13

Bold: P-value<0.05. The mean values of radial diffusivity were extracted from the global and regional white matter fiber tracts that associated with both carotid-femoral PWV and baroreflex sensitivity (see the bottom right of Figure 1). All models adjusted for age, sex, education level, systolic blood pressure, and total brain volume of white matter hyperintensity. Total brain volume of white matter hyperintensity was log-transformed before entered in the model. β=standardized regression coefficient, PWV=pulse wave velocity, and SE=standard error