Vivek Kumar Sharma, Senthil Kumar Subramanian, Vinayathan A, Sarah R, Balasubramaniam SR, Velkumary S,Study of Effect of Age and Gender Related Differences on Common Paper and Pencil Neurocognitive Tests in Adolescents (Published in Journal of Cilinical and Diagnostic Research. 2014 November: 8(11):). BC05-BC10
In this article typo errors were noticed. A correction has been done in the Title and [Table/Fig-1a,b,c],[Table/Fig-8],[Table/Fig-9a,b] and [Table/Fig-10a,Table/Fig-10b].
[Table/Fig-1a]:
Age wise comparison of neurocognitive test
| Parameters | Overall | Male | Female | ||||||
| N | F | p-value | N | F | p-value | N | F | p-value | |
| Height (cm) | 421 | 83.044 | <0.001 | 240 | 77.408 | <0.001 | 181 | 19.273 | <0.001 |
| Weight (kilogram) | 421 | 90.009 | <0.001 | 240 | 90.364 | <0.001 | 181 | 16.325 | <0.001 |
| LCT omission | 415 | 2.062 | .069 | 238 | 1.376 | 0.234 | 177 | 1.551 | 0.177 |
| LCT commission | 415 | 1.358 | 0.239 | 238 | 0.963 | 0.441 | 177 | 0.627 | 0.680 |
| LCT time (seconds) | 415 | 13.967 | <0.001 | 238 | 10.211 | <0.001 | 177 | 6.244 | <0.001 |
| TTA (seconds) | 437 | 39.847 | <0.001 | 248 | 21.502 | <0.001 | 189 | 18.353 | <0.001 |
| TTB (seconds) | 405 | 32.792 | <0.001 | 237 | 20.655 | <0.001 | 168 | 12.717 | <0.001 |
| RFFT Designs | 439 | 103.442 | <0.001 | 250 | 52.390 | <0.001 | 189 | 52.676 | <0.001 |
| RFFT Rotations | 439 | 6.696 | <0.001 | 250 | 4.360 | 0.001 | 189 | 2.030 | .076 |
| RFFT Perseverations | 439 | 85.339 | <0.001 | 250 | 51.391 | <0.001 | 189 | 31.250 | <0.001 |
LCT – Letter cancellation test, TTA - Trail making test part A, TTB – Trail making test part B, RFFT –Ruff figural fluency test. Analyzed using one way ANOVA, P<0.05 is considered statistically significant
[Table/Fig-1b]:
Agewise comparison of neurocognitive tests
| Parameters | Age(yr) | Mean ± SD | p-value 1 year difference | p-value 2 year difference | p-value 3 year difference | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall | Male | Female | Overall | Male | Female | Overall | Male | Female | Overall | Male | Female | |||||
| LCT time (seconds) | 12 | 117.71 ± 25.58 | 119.29 ± 24.83 | 116.43 ± 26.41 | 12 vs 13 | 1.000 | 1.000 | 1.000 | 12 vs 14 | 1.000 | 1.000 | 1.000 | 12 vs 15 | 0.117 | 1.000 | 0.083 |
| 13 | 115.56 ± 24.76 | 114.78 ± 23.62 | 116.56 ± 26.51 | 13 vs 14 | 1.000 | 0.990 | 1.000 | 13 vs 15 | 0.640 | 1.000 | 0.126 | 13 vs 16 | 0.030 | 0.658 | 0.198 | |
| 14 | 117.80 ± 19.47 | 123. 17 ± 20.65 | 111.14 ± 15.83 | 14 vs 15 | 0.144 | 0.937 | 1.000 | 14 vs 16 | 0.004 | 0.002 | 1.000 | 14 vs 17 | <0.001 | <0.001 | 0.012 | |
| 15 | 108.47 ± 16.61 | 114.13 ± 15.75 | 102.81 ± 15.71 | 15 vs 16 | 1.000 | 1.000 | 1.000 | 15 vs 17 | 0.002 | 0.002 | 0.634 | |||||
| 16 | 104.85 ± 18.88 | 106.13 ± 19.73 | 102.05 ± 16.99 | 16 vs 17 | 0.058 | 0.260 | 1.000 | |||||||||
| 17 | 94.73 ± 12.80 | 96.35 ± 13.60 | 90.95 ± 10.02 | |||||||||||||
| TTA (seconds) | 12 | 45.78 ± 6.23 | 46.32 ± 6.87 | 45.33 ± 5.72 | 12 vs 13 | 1.000 | 1.000 | 1.000 | 12 vs 14 | <0.001 | <0.001 | 0.001 | 12 vs 15 | <0.001 | <0.001 | <0.001 |
| 13 | 46.16 ± 6.59 | 46.05 ± 6.79 | 46.29 ± 6.43 | 13 vs 14 | <0.001 | <0.001 | <0.001 | 13 vs 15 | <0.001 | <0.001 | <0.001 | 13 vs 16 | <0.001 | <0.001 | <0.001 | |
| 14 | 40.15 ± 4.16 | 40.10 ± 3.67 | 40.20 ± 4.70 | 14 vs 15 | 1.000 | 1.000 | 1.000 | 14 vs 16 | 0.418 | 1.000 | 0.432 | 14 vs 17 | 0.003 | 0.133 | 0.125 | |
| 15 | 38.61 ± 4.90 | 38.26 ± 4.62 | 38.97 ± 5.23 | 15 vs 16 | 1.000 | 1.000 | 1.000 | 15 vs 17 | 0.728 | 1.000 | 1.000 | |||||
| 16 | 38.10 ± 6.17 | 38.65 ± 6.47 | 36.86 ± 5.35 | 16 vs 17 | 1.000 | 1.000 | 1.000 | |||||||||
| 17 | 36.77 ± 4.74 | 36.96 ± 4.54 | 36.36 ± 5.20 | |||||||||||||
| TTB (seconds) | 12 | 115.95 ± 28.73 | 113.26 ± 30.10 | 118.12 ± 27.75 | 12 vs 13 | 1.000 | 1.000 | 1.000 | 12 vs 14 | 1.000 | 1.000 | 1.000 | 12 vs 15 | <0.001 | <0.001 | <0.001 |
| 13 | 115.64 ± 30.23 | 118.55 ± 29.38 | 111.68 ± 31.45 | 13 vs 14 | 0.001 | 0.001 | 0.001 | 13 vs 15 | 0.001 | 0.001 | 0.001 | 13 vs 16 | <0.001 | <0.001 | 0.007 | |
| 14 | 112.10 ± 33.16 | 115.74 ± 31.85 | 107.54 ± 34.77 | 14 vs 15 | <0.001 | <0.001 | 0.006 | 14 vs 16 | 0.001 | 0.001 | 0.041 | 14 vs 17 | <0.001 | <0.001 | 0.001 | |
| 15 | 82.72 ± 21.78 | 83.32 ± 20.77 | 82.03 ± 23.21 | 15 vs 16 | 1.000 | 1.000 | 1.000 | 15 vs 17 | 1.000 | 1.000 | 1.000 | |||||
| 16 | 87.61 ± 21.80 | 89.34 ± 23.79 | 83.55 ± 15.97 | 16 vs 17 | 0.136 | 0.172 | 1.000 | |||||||||
| 17 | 75.77 ± 19.53 | 75.80 ± 20.37 | 75.70 ± 17.79 | |||||||||||||
LCT – Letter cancellation test, TTA - Trail making test part A, TTB – Trail making test part B, Analyzed using one way ANOVA with bonferroni post hoc test., P<0.05 is considered statistically significant
[Table/Fig-1c]:
Agewise comparison of neurocognitive tests
| Parameters | Age(yr) | Mean ± SD | p-value 1 year difference | p-value 2 year difference | p-value 3 year difference | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall | Male | Female | Overall | Male | Female | Overall | Male | Female | Overall | Male | Female | |||||
| RFFT Designs | 12 | 11.91 ± 2.85 | 11.35 ± 3.10 | 12.36 ± 2.57 | 12 vs 13 | 1.000 | 0.248 | 1.000 | 12 vs 14 | <0.001 | <0.001 | <0.001 | 12 vs 15 | <0.001 | <0.001 | <0.001 |
| 13 | 12.44 ± 3.21 | 13.24 ± 2.84 | 11.47 ± 3.41 | 13 vs 14 | <0.001 | <0.001 | <0.001 | 13 vs 15 | <0.001 | <0.001 | <0.001 | 13 vs 16 | <0.001 | <0.001 | <0.001 | |
| 14 | 17.29 ± 2.87 | 17.24 ± 2.58 | 17.34 ± 3.22 | 14 vs 15 | <0.001 | 0.082 | 0.017 | 14 vs 16 | <0.001 | 0.003 | 0.007 | 14 vs 17 | <0.001 | <0.001 | 0.057 | |
| 15 | 19.64 ± 3.23 | 19.44 ± 3.16 | 19.84 ± 3.34 | 15 vs 16 | 1.000 | 1.000 | 1.000 | 15 vs 17 | 1.000 | 1.000 | 1.000 | |||||
| 16 | 20.10 ± 4.02 | 19.98 ± 4.41 | 20.38 ± 3.01 | 16 vs 17 | 1.000 | 1.000 | 1.000 | |||||||||
| 17 | 20.40 ± 3.39 | 20.73 ± 3.53 | 19.72 ± 3.03 | |||||||||||||
| RFFT Rotations | 12 | 5.89 ± 2.25 | 5.82 ± 2.04 | 5.95 ± 2.44 | 12 vs 13 | 1.000 | 1.000 | 1.000 | 12 vs 14 | 1.000 | 1.000 | 1.000 | 12 vs 15 | 1.000 | 1.000 | 1.000 |
| 13 | 5.63 ± 2.12 | 5.68 ± 2.29 | 5.56 ± 1.93 | 13 vs 14 | 1.000 | 1.000 | 1.000 | 13 vs 15 | 1.000 | 1.000 | 1.000 | 13 vs 16 | 0.000 | 0.002 | 0.285 | |
| 14 | 5.92 ± 2.48 | 6.12 ± 2.61 | 5.69 ± 2.32 | 14 vs 15 | 1.000 | 1.000 | 1.000 | 14 vs 16 | 0.001 | 0.037 | 0.449 | 14 vs 17 | 0.189 | 1.000 | 1.000 | |
| 15 | 6.02± 2.98 | 6.47 ± 3.12 | 5.53 ± 2.81 | 15 vs 16 | 0.004 | 0.357 | 0.276 | 15 vs 17 | 0.442 | 1.000 | 0.869 | |||||
| 16 | 7.55 ± 2.91 | 7.73 ± 2.89 | 7.14 ± 2.99 | 16 vs 17 | 1.000 | 1.000 | 1.000 | |||||||||
| 17 | 6.91 ± 1.81 | 6.98 ± 1.74 | 6.76 ± 1.96 | |||||||||||||
| RFFT Perseverations | 12 | 22.05 ± 4.05 | 22.50 ± 4.34 | 21.69 ± 3.80 | 12 vs 13 | 1.000 | 1.000 | 1.000 | 12 vs 14 | <0.001 | <0.001 | <0.001 | 12 vs 15 | 0.001 | 0.001 | 0.001 |
| 13 | 21.79 ± 4.24 | 21.07 ± 4.01 | 22.65 ± 4.40 | 13 vs 14 | <0.001 | <0.001 | <0.001 | 13 vs 15 | <0.001 | <0.001 | <0.001 | 13 vs 16 | 0.001 | 0.001 | 0.001 | |
| 14 | 16.67 ± 3.93 | 16.37 ± 3.73 | 17.03 ± 4.17 | 14 vs 15 | 0.026 | 0.305 | 0.489 | 14 vs 16 | <0.001 | <0.001 | 0.001 | 14 vs 17 | 0.001 | 0.001 | 0.052 | |
| 15 | 14.42 ± 4.35 | 14.09 ± 3.80 | 14.78 ± 4.91 | 15 vs 16 | 0.001 | 0.018 | 0.393 | 15 vs 17 | 0.261 | 0.728 | 1.000 | |||||
| 16 | 11.33 ± 4.56 | 11.00 ± 4.75 | 12.10 ± 4.11 | 16 vs 17 | 0.717 | 1.000 | 1.000 | |||||||||
| 17 | 12.73 ± 4.31 | 12.25 ± 4.32 | 13.72 ± 4.20 | |||||||||||||
RFFT – Ruff figural fluency test, Analyzed using one way ANOVAwith bonferroni post hoc test,P<0.05 is considered statistically significant
[Table/Fig-8]:
Comparison of neurocognitive tests between male and female
| Parameters | Gender | N | Mean ± SD | p-value |
|---|---|---|---|---|
| Age (yr) | Female | 189 | 14.16 ± 1.69 | 0.001 |
| Male | 250 | 14.71 ± 1.73 | ||
| Height (cm) | Female | 181 | 1.51 ± 0.08 | <0.001 |
| Male | 240 | 1.56 ± 0.12 | ||
| Weight (Kilogram) | Female | 181 | 44.38 ± 7.24 | <0.001 |
| Male | 240 | 47.67± 10.03 | ||
| LCT omission | Female | 177 | 1.20 ± 1.69 | 0.181 |
| Male | 238 | 1.01 ± 1.27 | ||
| LCT commission | Female | 177 | 0.20 ± 0.49 | 0.353 |
| Male | 238 | 0.16 ± 0.46 | ||
| LCT time (seconds) | Female | 177 | 108.40 ± 22.12 | 0.208 |
| Male | 238 | 111.14 ± 21.72 | ||
| TTA (seconds) | Female | 189 | 41.35 ± 6.64 | 0.349 |
| Male | 248 | 40.75 ± 6.68 | ||
| TTB (seconds) | Female | 168 | 99.67 ± 31.29 | 0.528 |
| Male | 237 | 97.69 ± 30.98 | ||
| RFFT Designs | Female | 189 | 16.25 ± 4.77 | 0.020 |
| Male | 250 | 17.34 ± 4.82 | ||
| RFFT Rotations | Female | 189 | 6.00 ± 2.45 | 0.025 |
| Male | 250 | 6.54 ± 2.55 | ||
| RFFT Perseverations | Female | 189 | 17.71 ± 5.73 | 0.001 |
| Male | 250 | 15.78 ± 5.96 |
LCT – Letter cancellation test, TTA - Trail making test part A, TTB – Trail making test part B, RFFT – Ruff figural fluency test, Analyzed using unpaired t test, P<0.05 is considered statistically significant
[Table/Fig-9a]:
Agewise comparison of neurocognitive tests between male and female
| Parameters | Gender | 12 | 13 | 14 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean ± SD | p-value | N | Mean ± SD | p-value | N | Mean ± SD | p-value | ||
| Height (cm) | F | 41 | 1.44 ± 0.08 | 0.006 | 32 | 1.48 ± 0.07 | 0.630 | 33 | 1.52 ± 0.06 | 0.120 |
| M | 33 | 1.39 ± 0.07 | 41 | 1.48 ± 0.08 | 34 | 1.55 ± 0.09 | ||||
| Weight (kilogram) | F | 41 | 38.93 ± 7.59 | 0.006 | 32 | 41.75 ± 5.67 | 0.171 | 33 | 43.58 ± 3.79 | 0.448 |
| M | 33 | 34.97 ± 3.10 | 41 | 39.93 ± 5.51 | 34 | 44.47 ± 5.61 | ||||
| LCT omission | F | 42 | 0.83 ± 1.19 | 0.524 | 32 | 0.88 ± 1.18 | 0.350 | 29 | 1.83 ± 2.48 | 0.103 |
| M | 34 | 0.68 ± 0.88 | 41 | 1.12 ± 1.05 | 36 | 1.06 ± 1.17 | ||||
| LCT commission | F | 42 | 0.24 ± 0.48 | 0.397 | 32 | 0.25 ± 0.44 | 0.871 | 29 | 0.24 ± 0.58 | 0.532 |
| M | 34 | 0.15 ± 0.44 | 41 | 0.27 ± 0.50 | 36 | 0.17 ± 0.38 | ||||
| LCT time (seconds) | F | 42 | 116.43 ± 26.41 | 0.631 | 32 | 116.56 ± 26.51 | 0.763 | 29 | 111.14 ± 15.83 | 0.012 |
| M | 34 | 119.29±24.83 | 41 | 114.78 ± 23.62 | 36 | 123.17 ± 20.65 | ||||
| TTA (seconds) | F | 42 | 45.33 ± 5.72 | 0.495 | 34 | 46.29 ± 6.43 | 0.874 | 35 | 40.20 ± 4.70 | 0.921 |
| M | 34 | 46.32 ± 6.87 | 41 | 46.05 ± 6.79 | 39 | 40.10 ± 3.67 | ||||
| TTB (seconds) | F | 42 | 118.12±27.75 | 0.468 | 28 | 111.68 ± 31.45 | 0.365 | 28 | 107.54 ± 34.77 | 0.333 |
| M | 34 | 113.26 ± 30.10 | 38 | 118.55 ± 29.38 | 35 | 115.74 ± 31.85 | ||||
| RFFT Designs | F | 42 | 12.36 ± 2.57 | 0.127 | 34 | 11.47 ± 3.41 | 0.016 | 35 | 17.34 ± 3.22 | 0.882 |
| M | 34 | 11.35 ± 3.10 | 41 | 13.24 ± 2.84 | 41 | 17.24 ± 2.58 | ||||
| RFFT Rotations | F | 42 | 5.95 ± 2.44 | 0.806 | 34 | 5.56 ± 1.93 | 0.802 | 35 | 5.69 ± 2.32 | 0.447 |
| M | 34 | 5.82 ± 2.04 | 41 | 5.68 ± 2.29 | 41 | 6.12 ± 2.61 | ||||
| RFFT Perseverations | F | 42 | 21.69 ± 3.80 | 0.389 | 34 | 22.65 ± 4.40 | 0.110 | 35 | 17.03 ± 4.17 | 0.467 |
| M | 34 | 22.50 ± 4.34 | 41 | 21.07 ± 4.01 | 41 | 16.37 ± 3.73 | ||||
F-Female,M -Male, LCT – Letter cancellation test, TTA - Trail making test part A, TTB – Trail making test part B, RFFT – Ruff figural fluency test, Analyzed using Analyzed using unpaired t test, P<0.05 is considered statistically significant
[Table/Fig-9b]:
Agewise comparison of neurocognitive tests between male and female
| Parameters | Gender | 15 | 16 | 17 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean ± SD | p-value | N | Mean ± SD | p-value | N | Mean ± SD | p-value | ||
| Height (cm) | F | 32 | 1.55 ± 0.06 | 0.036 | 19 | 1.60 ± 0.07 | 0.037 | 24 | 1.54 ± 0.07 | 0.001 |
| M | 34 | 1.58 ± 0.08 | 48 | 1.64 ± 0.07 | 50 | 1.67 ± 0.07 | ||||
| Weight (kilogram) | F | 32 | 48.53 ± 6.70 | 0.457 | 19 | 50.21 ± 6.01 | 0.001 | 24 | 48.17 ± 5.26 | 0.001 |
| M | 34 | 47.26 ± 7.02 | 48 | 57.77 ± 6.15 | 50 | 55.16 ± 6.76 | ||||
| LCT omission | F | 32 | 1.38 ± 2.01 | 0.892 | 21 | 1.33 ± 1.46 | 0.233 | 21 | 1.19 ± 1.40 | 0.468 |
| M | 32 | 1.44 ± 1.64 | 46 | 0.91 ± 1.26 | 49 | 0.92 ± 1.44 | ||||
| LCT commission | F | 32 | 0.16 ±0.37 | 0.236 | 21 | 0.24 ± 0.77 | 0.822 | 21 | 0.05 ± 0.22 | 0.463 |
| M | 32 | 0.06 ± 0.25 | 46 | 0.20 ± 0.69 | 49 | 0.10 ± 0.31 | ||||
| LCT time (seconds) | F | 32 | 102.81 ± 15.71 | 0.005 | 21 | 102.05 ± 16.99 | 0.416 | 21 | 90.95 ± 10.02 | 0.107 |
| M | 32 | 114.13 ± 15.75 | 46 | 106.13 ± 19.73 | 49 | 96.35 ± 13.60 | ||||
| TTA (seconds) | F | 32 | 38.97 ± 5.23 | 0.564 | 21 | 36.86 ± 5.35 | 0.271 | 25 | 36.36 ± 5.20 | 0.605 |
| M | 34 | 38.26 ± 4.62 | 48 | 38.65 ± 6.47 | 52 | 36.96 ± 4.54 | ||||
| TTB (seconds) | F | 30 | 82.03 ± 23.21 | 0.815 | 20 | 83.55 ± 15.97 | 0.323 | 20 | 75.70 ± 17.79 | 0.985 |
| M | 34 | 83.32 ± 20.77 | 47 | 89.34 ± 23.79 | 49 | 75.80 ± 20.37 | ||||
| RFFT Designs | F | 32 | 19.84 ± 3.34 | 0.617 | 21 | 20.38 ± 3.01 | 0.705 | 25 | 19.72 ± 3.03 | 0.223 |
| M | 34 | 19.44 ± 3.16 | 48 | 19.98 ± 4.41 | 52 | 20.73 ± 3.53 | ||||
| RFFT Rotations | F | 32 | 5.53 ± 2.81 | 0.204 | 21 | 7.14 ± 2.99 | 0.446 | 25 | 6.76 ± 1.96 | 0.619 |
| M | 34 | 6.47 ± 3.12 | 48 | 7.73 ± 2.89 | 52 | 6.98 ± 1.74 | ||||
| RFFT Perseverations | F | 32 | 14.78 ± 4.91 | 0.522 | 21 | 12.10 ± 4.11 | 0.363 | 25 | 13.72 ± 4.20 | 0.162 |
| M | 34 | 14.09 ± 3.80 | 48 | 11.00 ± 4.75 | 52 | 12.25 ± 4.32 | ||||
LCT – Letter cancellation test, TTA - Trail making test part A, TTB – Trail making test part B, RFFT – Ruff figural fluency test, Analyzed using Analyzed using unpaired t test, P<0.05 is considered statistically significant
[Table/Fig-10a]:
Correlation between the neurocognitive tests
| TTA | TTB | RFFT Designs | RFFT Perseverations | ||
|---|---|---|---|---|---|
| LCT time | r-value | .121 | .320 | -.185 | .169 |
| p-value | .014 | <0.001 | <0.001 | 0.001 | |
| N | 414 | 398 | 415 | 415 | |
| TTA | r-value | .275 | -.438 | .421 | |
| p-value | <0.001 | <0.001 | <0.001 | ||
| N | 404 | 437 | 437 | ||
| TTB | r-value | -.352 | .296 | ||
| p-value | <0.001 | <0.001 | |||
| N | 405 | 405 | |||
| RFFT Designs | r-value | -.868 | |||
| p-value | <0.001 | ||||
| N | 439 |
LCT – Letter cancellation test, TTA - Trail making test part A, TTB – Trail making test part B, RFFT – Ruff figural fluency test Analyzed using Pearson’s correlation, P<0.05 is considered statistically significant
[Table/Fig-10b]:
Correlation between neurocognitive test after adjusting for group
| TTA | TTB | RFFT Designs | RFFT Perseverations | ||
|---|---|---|---|---|---|
| LCT time | r-value | -.068 | .153 | .072 | -.071 |
| p-value | .189 | 0.003 | 0.161 | 0.166 | |
| df | 377 | 377 | 377 | 377 | |
| TTA | r-value | .027 | -.113 | .102 | |
| p-value | 0.595 | 0.028 | 0.047 | ||
| df | 377 | 377 | 377 | ||
| TTB | r-value | -.038 | -.033 | ||
| p-value | .459 | 0.522 | |||
| df | 377 | 377 | |||
| RFFT Designs | r-value | -.754 | |||
| p-value | <0.001 | ||||
| df | 377 |
LCT – Letter cancellation test, TTA - Trail making test part A, TTB – Trail making test part B, RFFT – Ruff figural fluency test, Correlation after adjusting for age, P<0.05 is considered statisticallysignificant
