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. Author manuscript; available in PMC: 2016 Mar 31.
Published in final edited form as: Biochemistry. 2015 Mar 20;54(12):2126–2135. doi: 10.1021/acs.biochem.5b00010

Table 2.

Inhibitory Activity of Largazole Analogues against Class I HDACs (IC50, nM)a
HDAC1 HDAC2 HDAC3 HDAC8
Largazole 2.5 4.2 2.8 228
1 2.0 3.4 2.6 255
2 42 70 42 ~10,000
3 13 21 15 1500
a

Reported in reference 26.