Table 2. Risk for colorectal cancer according to regular use of aspirin and/or NSAIDs, stratified by the genotypes of rs2965667, rs10505806, and rs16973225.
| rs2965667b | Non-regular aspirin and/or NSAID users | Regular aspirin and/or NSAID usersa | P-value |
|---|---|---|---|
| TT | |||
| Cases/Controls | 5,933/5,088 | 2,325/3,119 | |
| Base Model (OR)d | 1.00 | 0.66 (0.61-0.70) | 7.7×10-33 |
| Multivariable-Adjusted Model (OR)e | 1.00 | 0.63 (0.59-0.68) | 2.3×10-35 |
| TA or AA | |||
| Cases/Controls | 246/244 | 130/102 | |
| Base Model (OR)d | 1.00 | 1.89 (1.27-2.81) | 0.002 |
| Multivariable-Adjusted Model (OR)e | 1.00 | 1.76 (1.16-2.66) | 0.008 |
| P for interactionf | 4.6×10-9 | ||
|
| |||
| rs10505806b | Non-regular aspirin and/or NSAID users | Regular aspirin and/or NSAID usersa | P-value |
|
| |||
| AA | |||
| Cases/Controls | 5,896/5,039 | 2,301/3,092 | |
| Base Model (OR)d | 1.00 | 0.66 (0.61-0.70) | 8.7×10-33 |
| Multivariable-Adjusted Model (OR)e | 1.00 | 0.63 (0.59-0.68) | 4.2×10-35 |
| AT or TT | |||
| Cases/Controls | 283/293 | 154/129 | |
| Base Model (OR)d | 1.00 | 1.56 (1.12-2.16) | 0.008 |
| Multivariable-Adjusted Model (OR)e | 1.00 | 1.42 (1.01-2.00) | 0.045 |
| P for interactionf | 5.5×10-8 | ||
|
| |||
| rs16973225c | Non-regular aspirin and/or NSAID users | Regular aspirin and/or NSAID usersa | P-value |
|
| |||
| AA | |||
| Cases/Controls | 5,686/4,840 | 2,181/2,909 | |
| Base Model (OR)d | 1.00 | 0.66 (0.62-0.71) | 1.9×10-30 |
| Multivariable-Adjusted Model (OR)e | 1.00 | 0.63 (0.59-0.68) | 3.5×10-33 |
| AC or CC | |||
| Cases/Controls | 491/492 | 274/311 | |
| Base Model (OR)d | 1.00 | 0.97 (0.78-1.20) | 0.760 |
| Multivariable-Adjusted Model (OR)e | 1.00 | 0.93 (0.75-1.17) | 0.550 |
| P for interactionf | 8.2×10-9 | ||
The numbers of cases and controls were from the Base Model. For the SNP rs16973225, the total sample size is slightly smaller than in Table 1 due to missing genotype (n=3).
Regular use of aspirin-only, NSAIDs-only, or both aspirin and NSAIDs
SNPs rs2965667 and rs10505806 were identified from conventional logistic regression analysis.
SNP rs16973225 was identified from case-only interaction analysis.
ORs in Base Models are adjusted for age at the reference time, sex, center, and the first three principal components from EIGENSTRAT.
ORs in Multivariable-Adjusted Models are adjusted for age at the reference time, sex, center, the first three principal components, smoking status (never, former, or current smoker), BMI, alcohol consumption, and red meat consumption.
P-values for interactions were calculated after adjusting for age at the reference time, sex, center, and the first three principal components from EIGENSTRAT.