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. 1994 May 24;91(11):4673–4677. doi: 10.1073/pnas.91.11.4673

Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer.

I Sehgal 1, S Powers 1, B Huntley 1, G Powis 1, M Pittelkow 1, N J Maihle 1
PMCID: PMC43850  PMID: 8197117

Abstract

After therapeutic hormone deprivation, prostate cancer cells often develop androgen-insensitive growth through mechanisms thus far undefined. Neuropeptides have been previously implicated as growth factors in some prostate cancers. Here, we demonstrate that androgen-sensitive LNCaP human prostate cancer cells produce and secrete neurotensin following androgen withdrawal. We show that while LNCaP cells express the neurotensin receptor, only androgen-deprived cells exhibit a growth response to exogenous neurotensin. We further demonstrate that androgen-stimulated cells may be refractory to exogenous neurotensin due to androgen induction of a metalloprotease active toward neurotensin. Thus, prostate cancer cells deprived of androgen develop an alternative autocrine growth mechanism involving neurotensin.

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Selected References

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