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. 2015 Jan 24;6(4):1967–1980. doi: 10.18632/oncotarget.2806

Figure 6. An inverse relationship between DUSP2 and HIF-1α in ER negative breast cancer associates with decreased relapse-free survival.

Figure 6

(A) Kaplan-Meier plots of relapse-free survival (RFS) in a dataset of patients with ER-negative breast cancer (n = 788), stratified by DUSP2 expression. Data was obtained from the Kaplan-Meier plotter database [34]. The P value was calculated by a log-rank test. (B) Similar analysis was performed in the same patient database but RFS stratified by HIF-1α expression. (C) A schematic model of hypoxia-mediated lapatinib resistance.