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. 2014 Dec 11;6(4):2193–2205. doi: 10.18632/oncotarget.3059

Figure 2. DCLK1 methylation is dysregulated and correlated to DCLK1 mRNA expression in the TCGA's RCC human methylation 450K dataset.

Figure 2

A) Single-linkage hierarchichal clustering demonstrating a unique DCLK1 methylation signature in tumor compared to matched adjacent tissue. B) Schematic of human DCLK1 chromosomal, gene, transcripts, and promoter locations based on the ENSEMBL database entry. C) Bar graph of individual DCLK1 methylation markers demonstrating a tendency towards hypomethylation in α- and β-promoter regions and overall. D) Isoform specific mRNA expression of DCLK1 isoforms 1 and 4 in normal compared to RCC tumor tissue. Isoform 1 is driven by the α-promoter and isoform 4 is driven by the β-promoter. E) Histone H3K27ac at Chr13:36553414 (HM450k probe cg13805761) is strongly associated with DCLK1 mRNA expression (p<0.0001).