Table 2. Cellular distribution of DA receptors in the cortex and striatum of rodents.
D1 | D2 | D3 | D4 | D5 | |
---|---|---|---|---|---|
Striatum | |||||
dSPNs | +++ (>90%) | – | + (50%) | + (<10%) | – |
iSPNs | + (<10%) | +++ (>90%) | + (<10%) | + (<10%) | + (<10%) |
Cholinergic interneurons | + (<20%) | ++ (>80%) | – | – | ++ (>80%) |
PV+ interneurons | + (>70%) | ||||
NPY/SOM/NO+ interneuron | + (<10%) | + (>70%) | |||
CR+ interneurons | + (50%) | ||||
Cortex | |||||
L2/3 pyramidal neurons | ++ (<20%) | + (<10%) | + | + | |
L5/6 pyramidal neurons | ++ (20–40%) | + (25%) | + | + | |
L2-6 interneurons | ++ (30–60%)* | + (20%)* | + | + | + |
For the most part PV+ interneurons