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. 1955 Apr;34(4):581–589. doi: 10.1172/JCI103106

EFFECTS OF HEPARIN ON THE LIPOPROTEINS IN HYPERLIPEMIA. AN ELECTROPHORETIC STUDY OF THE SERUM ALPHA AND BETA LIPOPROTEINS AFTER THEIR SEPARATION BY FRACTIONATION OF THE PLASMA PROTEINS OR ULTRACENTRIFUGAL FLOTATION 1

Franz S M Herbst 1,2, Walter F Lever 1,2, Mary E Lyons 1,2, Nancy A Hurley 1,2
PMCID: PMC438663  PMID: 14367511

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOYLE E., BRAGDON J. H., BROWN R. K. Role of heparin in in vitro production of alpha1 lipoproteins in human plasma. Proc Soc Exp Biol Med. 1952 Nov;81(2):475–477. doi: 10.3181/00379727-81-19915. [DOI] [PubMed] [Google Scholar]
  2. BROWN R. K., BOYLE E., ANFINSEN C. B. The enzymatic transformation of lipoproteins. J Biol Chem. 1953 Sep;204(1):423–434. [PubMed] [Google Scholar]
  3. DE LALLA O. F., GOFMAN J. W. Ultracentrifugal analysis of serum lipoproteins. Methods Biochem Anal. 1954;1:459–478. doi: 10.1002/9780470110171.ch16. [DOI] [PubMed] [Google Scholar]
  4. GRASSMANN W., HANNIG K. Ein quantitatives Verfahren zur Analyse der Serumproteine durch Papierelektrophorese. Hoppe Seylers Z Physiol Chem. 1952;290(1-2):1–27. [PubMed] [Google Scholar]
  5. HERBST F. S., HURLEY N. A. Effects of heparin on alimentary hyperlipemia: an electrophoretic study. J Clin Invest. 1954 Jun;33(6):907–911. doi: 10.1172/JCI102964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. JONES H. B., GOFMAN J. W., LINDGREN F. T., LYON T. P., GRAHAM D. M., STRISOWER B., NICHOLS A. V. Lipoproteins in atherosclerosis. Am J Med. 1951 Sep;11(3):358–380. doi: 10.1016/0002-9343(51)90171-4. [DOI] [PubMed] [Google Scholar]
  7. LEVER W. F., GURD F. R. N., UROMA E., BROWN R. K., BARNES B. A., SCHMID K., SCHULTZ E. L. Chemical, clinical and immunological studies on the products of human plasma fractionation XL. Quantitative separation and determination of the protein components in small amounts of normal human plasma. J Clin Invest. 1951 Jan;30(1):99–111. doi: 10.1172/JCI102423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LEVER W. F., HERBST F. S., HURLEY N. A. Idiopathic hyperlipemia and primary hypercholesteremic xanthomatosis. IV. Effects of prolonged administration of heparin on serum lipids in idiopathic hyperlipemia. AMA Arch Derm. 1955 Feb;71(2):150–157. doi: 10.1001/archderm.1955.01540260008003. [DOI] [PubMed] [Google Scholar]
  9. LEVER W. F., HERBST F. S., LYONS M. E. Idiopathic hyperlipemia and primary hypercholesteremic xanthomatosis. V. Analysis of serum lipoproteins by means of ultracentrifuge before and after administration of heparin. AMA Arch Derm. 1955 Feb;71(2):158–171. doi: 10.1001/archderm.1955.01540260016005. [DOI] [PubMed] [Google Scholar]
  10. LEVER W. F., SMITH P. A., HURLEY N. A. Effects of intravenous heparin on the plasma lipoproteins in primary hypercholesteremic xanthomatosis and idiopathic hyperlipemia. Science. 1953 Nov 27;118(3074):653–654. doi: 10.1126/science.118.3074.653. [DOI] [PubMed] [Google Scholar]
  11. LEVER W. F., SMITH P. A., HURLEY N. A. Idiopathic hyperlipemia and primary hypercholesteremic xanthomatosis. II. Analysis of the plasma proteins and lipids by means of electrophoresis and fractionation of the plasma proteins; effect of high speed centrifugation and of extraction with ether on the plasma proteins and lipids. J Invest Dermatol. 1954 Jan;22(1):53–69. doi: 10.1038/jid.1954.8. [DOI] [PubMed] [Google Scholar]
  12. LEVER W. F., SMITH P. A., HURLEY N. A. Idiopathic hyperlipemia and primary hypercholesteremic xanthomatosis. III. Effects of intravenously administered heparin on the plasma proteins and lipids. J Invest Dermatol. 1954 Jan;22(1):71-84; discussion, 84-7. doi: 10.1038/jid.1954.9. [DOI] [PubMed] [Google Scholar]
  13. NIKKILA E., GRASBECK R. Heparin in lipoid nephrosis; observations of the effects on edema, proteinuria, serum proteins, lipids and lipoproteins. Acta Med Scand. 1954;150(1):39–46. [PubMed] [Google Scholar]
  14. SHORE B., NICHOLS A. V., FREEMAN N. K. Evidence for lipolytic action by human plasma obtained after intravenous administration of heparin. Proc Soc Exp Biol Med. 1953 Jun;83(2):216–220. doi: 10.3181/00379727-83-20312. [DOI] [PubMed] [Google Scholar]
  15. SWAHN B. A method for localization and determination of serum lipids after electrophoretical separation on filter paper. Scand J Clin Lab Invest. 1952;4(2):98–103. doi: 10.3109/00365515209060643. [DOI] [PubMed] [Google Scholar]
  16. WILLIAMS G. R. Lipoprotein transformations under the influence of heparin and Clostridium welchii alpha-toxin. Biochim Biophys Acta. 1954 Jan;13(1):72–79. doi: 10.1016/0006-3002(54)90273-5. [DOI] [PubMed] [Google Scholar]

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