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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Neuropharmacology. 2015 Jan 31;93:146–154. doi: 10.1016/j.neuropharm.2015.01.013

Figure 3.

Figure 3

Dopaminergic changes in the striatum 16 h following the last self-administration session. Rats were allowed to self-administer METH (0.12 mg/infusion) or saline (10 μl/infusion) for 7 d (8 h/d) and were sacrificed 16 h after the last session. METH self-administration resulted in a reduction in DAT function (Panel A) and a trend toward a reduction in D2 receptor immunoreactivity (Panel B). Striatal DA content was reduced in METH self-administering rats and DOPAC content was increased compared to saline self-administering rats (Panels C & D). Insert: Representative D2 immunoreactivity of Saline (left) and METH (right) self-administering rats depicted in Panel B. *p<0.05 compared to saline self-administrating rats. †p<0.10 compared to saline self-administering rats.