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. Author manuscript; available in PMC: 2015 Apr 7.
Published in final edited form as: Neuron. 2014 May 21;82(4):773–780. doi: 10.1016/j.neuron.2014.04.043

Figure 2. Prominent Overtransmission of Private LOF Variants in Intolerant Genes.

Figure 2

Relative transmission ratios (RTRs) are displayed for variants categorized by their functionality (blue: loss-of-function [LOF] variants; red: MODERATE-effect variants; and green: LOW-effect variants), minor allele frequencies (private, rare, or common), and gene intolerance. Detailed definition for LOF, MODERATE-, and LOW-effect variants is provided in the Supplemental Experimental Procedures. *p < 0.05. Error bars indicate 95% confidential intervals. p values for RTRs were calculated by one-sided permutation analysis with random shuffling of the case-control status.