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. 1955 Jul;34(7 Pt 1):1126–1146. doi: 10.1172/JCI103162

BIOSYNTHETIC DETERMINATION WITH RADIOACTIVE SULFUR OF TURN-OVER RATES OF VARIOUS PLASMA PROTEINS IN NORMAL AND CIRRHOTIC MAN 1,2

Wade Volwiler 1,3, Patrick D Goldsworthy 1, Marion P MacMartin 1, Patricia Ann Wood 1, Ian R Mackay 1,4, Kenneth Fremont-Smith 1
PMCID: PMC438864  PMID: 14392228

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMSTRONG S. H., Jr, McLEOD K., WOLTER J., KUKRAL J. The persistence in the blood of the radioactive label of albumin, gamma globulins, globulins of intermediate mobility studied with S35 and paper electrophoresis: methods and preliminary results. J Lab Clin Med. 1954 Jun;43(6):918–937. [PubMed] [Google Scholar]
  2. DIXON F. J., TALMAGE D. W., MAURER P. H., DEICHMILLER M. The half-life on homologous gamma globulin (antibody) in several species. J Exp Med. 1952 May;95(5):313–318. doi: 10.1084/jem.96.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FORKER L. L., CHAIKOFF I. L. Turnover of serum proteins in diabetes as studied with S35 labeled proteins. J Biol Chem. 1952 May;196(2):829–840. [PubMed] [Google Scholar]
  4. FRAENKEL-CONRAT J., FRAENKEL-CONRAT H. The essential groups of insulin. Biochim Biophys Acta. 1950 Mar;5(1):89–97. doi: 10.1016/0006-3002(50)90152-1. [DOI] [PubMed] [Google Scholar]
  5. GABRIELI E. R., GOULIAN D., Jr, KINERSLY T., COLLET R. Zone paper electrophoresis studies on radioiodinated human serum albumin. J Clin Invest. 1954 Feb;33(2):136–141. doi: 10.1172/JCI102880. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GOFMAN J. W., JONES H. B., LINDGREN F. T., LYON T. P., ELLIOTT H. A., STRISOWER B. Blood lipids and human atherosclerosis. Circulation. 1950 Aug;2(2):161–178. doi: 10.1161/01.cir.2.2.161. [DOI] [PubMed] [Google Scholar]
  7. Gibson J. G., Evans W. A. CLINICAL STUDIES OF THE BLOOD VOLUME. I. CLINICAL APPLICATION OF A METHOD EMPLOYING THE AZO DYE "EVANS BLUE" AND THE SPECTROPHOTOMETER. J Clin Invest. 1937 May;16(3):301–316. doi: 10.1172/JCI100859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HUMPHREY J. H., McFARLANE A. S. Rate of elimination of homologous globulins (including antibody) from the circulation. Biochem J. 1954 Jun;57(2):186–191. doi: 10.1042/bj0570186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KINSELL L. W., MARGEN S. Studies in methionine metabolism; the fate of intravenously administered S35-labeled-methionine in normal adult males, in patients with chronic hepatic disease, idiopathic hypoproteinemia and Cushing's syndrome. J Clin Invest. 1950 Feb;29(2):238–250. doi: 10.1172/JCI102251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KUNKEL H. G., SLATER R. J. Zone electrophoresis in a starch supporting medium. Proc Soc Exp Biol Med. 1952 May;80(1):42–44. doi: 10.3181/00379727-80-19516. [DOI] [PubMed] [Google Scholar]
  11. KUNKEL H. G., TISELIUS A. Electrophoresis of proteins on filter paper. J Gen Physiol. 1951 Sep;35(1):89–118. doi: 10.1085/jgp.35.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LEE N. D., ANDERSON J. T., MILLER R., WILLIAMS R. H. Incorporation of labeled cystine into tissue protein and subcellular structures. J Biol Chem. 1951 Oct;192(2):733–742. [PubMed] [Google Scholar]
  13. LEVER W. F., GURD F. R. N., UROMA E., BROWN R. K., BARNES B. A., SCHMID K., SCHULTZ E. L. Chemical, clinical and immunological studies on the products of human plasma fractionation XL. Quantitative separation and determination of the protein components in small amounts of normal human plasma. J Clin Invest. 1951 Jan;30(1):99–111. doi: 10.1172/JCI102423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. LINDGREN F. T., ELLIOTT H. A., GOFMAN J. W. The ultracentrifugal characterization and isolation of human blood lipids and lipoproteins, with applications to the study of atherosclerosis. J Phys Colloid Chem. 1951 Jan;55(1):80–93. doi: 10.1021/j150484a010. [DOI] [PubMed] [Google Scholar]
  15. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  16. MADDEN R. E., GOULD R. G. The turnover rate of fibrinogen in the dog. J Biol Chem. 1952 May;196(2):641–650. [PubMed] [Google Scholar]
  17. MILLER L. L., BALE W. F. Synthesis of all plasma protein fractions except gamma globulins by the liver; the use of zone electrophoresis and lysine-epsilon-C14 to define the plasma proteins synthesized by the isolated perfused liver. J Exp Med. 1954 Feb;99(2):125–132. doi: 10.1084/jem.99.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. MILLER L. L., BLY C. G., BALE W. F. Plasma and tissue proteins produced by non-hepatic rat organs as studied with lysine-epsilon-C14; gamma globulins the chief plasma protein fraction produced by non-hepatic tissues. J Exp Med. 1954 Feb;99(2):133–153. doi: 10.1084/jem.99.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. MYANT N. B. Observation on the metabolism of human gamma globulin labelled by radioactive iodine. Clin Sci. 1952 May;11(2):191–201. [PubMed] [Google Scholar]
  20. NIKLAS A., POLIWODA H. Zur Frage der biologischen Halbwertszeit menschlicher Albumine und Globuline. Biochem Z. 1954;326(2):97–106. [PubMed] [Google Scholar]
  21. PETERSON E. A., GREENBERG D. M. Characteristics of the amino acid-incorporating system of liver homogenates. J Biol Chem. 1952 Jan;194(1):359–375. [PubMed] [Google Scholar]
  22. Pirie N. W. Studies in the sulphur metabolism of the dog: The metabolism of methionine and related sulphides. Biochem J. 1932;26(6):2041–2045. doi: 10.1042/bj0262041. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. RATNOFF O. D., MENZIE C. A new method for the determination of fibrinogen in small samples of plasma. J Lab Clin Med. 1951 Feb;37(2):316–320. [PubMed] [Google Scholar]
  24. RUSS E. M., EDER H. A., BARR D. P. Protein-lipid relationships in human plasma. I. In normal individuals. Am J Med. 1951 Oct;11(4):468–479. doi: 10.1016/0002-9343(51)90182-9. [DOI] [PubMed] [Google Scholar]
  25. SHOENBERGER J. A., KROLL G., SAKAMOTO A., KARK R. M. Investigation of the permeability factor in ascites and edema using albumin tagged with I 131. Gastroenterology. 1952 Dec;22(4):607–622. [PubMed] [Google Scholar]
  26. SOLOMON A. K. Equations for tracer experiments. J Clin Invest. 1949 Nov;28(6 Pt 1):1297–1307. doi: 10.1172/JCI102197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SOLOMON A. K. The kinetics of biological processes; special problems connected with the use of tracers. Adv Biol Med Phys. 1953;3:65–97. doi: 10.1016/b978-1-4831-9926-9.50006-9. [DOI] [PubMed] [Google Scholar]
  28. SPERRY W. M., WEBB M. A revision of the Schoenheimer-Sperry method for cholesterol determination. J Biol Chem. 1950 Nov;187(1):97–106. [PubMed] [Google Scholar]
  29. STEINBOCK H. L., TARVER H. Plasma protein. V. The effect of the protein content of the diet on turnover. J Biol Chem. 1954 Jul;209(1):127–132. [PubMed] [Google Scholar]
  30. SURGENOR D. M., ALEXANDER B., GOLDSTEIN R., SCHMID K. A system for the separation of the protein components of human plasma. II. The components of the clotting process. J Phys Colloid Chem. 1951 Jan;55(1):94–101. doi: 10.1021/j150484a011. [DOI] [PubMed] [Google Scholar]

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