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. 2010 Jul 10;1(1):45–51. doi: 10.1007/s13317-010-0008-2

Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis

Alessia Alunno 1, Elena Bartoloni 1, Giuseppe Nocentini 2, Onelia Bistoni 1, Simona Ronchetti 2, Maria Grazia Petrillo 2, Carlo Riccardi 2, Roberto Gerli 1,✉
PMCID: PMC4389058  PMID: 26000107

Abstract

Regulatory T cells (Treg) are a CD4+ lymphocyte subset involved in self-tolerance and autoimmunity prevention. There is evidence for a phenotypic and/or functional impairment of this cell subset during the natural history of several chronic autoimmune/inflammatory diseases, including rheumatoid arthritis (RA). Although the intracellular transcription factor FoxP3 is thought to be the master regulator of Treg cell function, a number of other molecules expressed on the cell surface have been proposed for the identification of Treg cells. This is important in order to favour their possible selective isolation and in the development of new therapeutic strategies. In the present paper, available data on phenotypic and functional characterization of Treg cells in both peripheral blood and synovial fluid from RA patients are reviewed and their possible pathogenic role in triggering and perpetuating rheumatoid joint inflammation is discussed.

Keywords: Treg cells, Rheumatoid arthritis, FoxP3 GITR

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