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. Author manuscript; available in PMC: 2015 Jul 4.
Published in final edited form as: Neurosignals. 2014 Oct 8;22(2):65–78. doi: 10.1159/000367896

Table 1.

Biophysical properties and positive modulators of SK and IK channels adapted from Aldrich et al. [71]

Channel Human gene Single-channel conductance, pS Ca2+ sensitivity, pEC50 Positive modulators
SK1 KCNN1 9.2 6.2–6.5 1-EBIO, DCEBIO, NS309, riluzole, SKA-31, GW542573X
SK2 KCNN2 9.5 6.2–6.5 1-EBIO, DCEBIO, NS309, riluzole, SKA-31, CyPPA, NS13001
SK3 KCNN3 – 6.0–6.5 1-EBIO, DCEBIO, NS309, riluzole, SKA-31, CyPPA, NS13001
IK KCNN4 11–40 6.1–7.0 1-EBIO, DCEBIO, NS309, riluzole, SKA-31, SKA-111 [60]