Fig. 4. Serial measurement of the left ventricular ejection fraction (LVEF) for animals receiving Bundle versus Control therapy as determined by echocardiography.

All animals that remained free of major adverse events were assessed with echocardiography at the time points noted (BND n=12 and Control n=4). Mean LVEF was compared at each time point with asterisks noting statistically significant differences with p-values as indicated.