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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Leukemia. 2014 Oct 14;29(4):909–917. doi: 10.1038/leu.2014.303

Figure 1. Overexpression of U2AF1 (S34F) alters the distribution of known and novel splice junctions.

Figure 1

Expression of splice junctions from RNA-seq of primary human CD34+ cells transfected with either WT or S34F mutant U2AF1. (a) Known splice junctions. (b, c and d) Novel splice junctions: (b) Known splice acceptor/donor in novel combination; (c) Novel splice acceptor/Known splice donor sites; (d) Known splice acceptor/Novel splice donor sites. Numbers in each panel indicate significantly altered (FDR<5%) splice junctions with a | log2(fold change) | >2.