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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Hypertension. 2015 Mar 23;65(5):1118–1125. doi: 10.1161/HYPERTENSIONAHA.114.05096

Figure 1.

Figure 1

Expression of TGFβ1 and the EMT markers MMP3, FN1, and Col1a in human renal proximal tubule cells (RPTCs) from subjects carrying DRD2 wild-type (D2R-WT) or D2R-SNPs.

A. mRNA expressions of DRD2, TGFβ1, MMP3, FN1, and Col1a in RPTC-D2R-WT or RPTC-D2R-SNPs were quantified by qRT-PCR; GAPDH mRNA was used for normalization of the data, n = 4-5/ group. *P< 0.05 vsD2R-WT, t-test.

B. mRNA expressions of TGFβ1, MMP3, FN1, and Col1a in RPTC-D2R-WT after siRNA mediated DRD2 silencing were quantified as above, n = 4/group. * P< 0.05 vs non-silencing siRNA, t-test.

C. mRNA expressions of TGFβ1, MMP3, FN1, and Col1a in RPTC-D2R-SNPs after transfection of a DRD2 plasmid were quantified as above, n = 5/group. * P< 0.05 vs empty vector, t-test.