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. Author manuscript; available in PMC: 2016 Apr 9.
Published in final edited form as: Cell. 2015 Apr 9;161(2):348–360. doi: 10.1016/j.cell.2015.02.044

Figure 7. A model for BtBimA, BpBimA and BmBimA nucleation and actin tail and MNGC formation.

Figure 7

(A) BtBimA activates host Arp2/3 complex using its WCA domain to nucleate branched actin networks. BpBimA nucleates and elongates filaments from barbed ends using its two N-terminal WH2 motifs, while BmBimA exhibits the same activities using its single WH2 motif to generate bundled filaments. (B) BtBimA and Arp2/3 form shorter tails with branched actin networks. BpBimA and BmBimA produce longer tails of bundled filaments. (C) Burkholderia synthesizing BtBimA or BpBimA form more actin tails and generate larger MNGCs compared with bacteria producing BmBimA.