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. 1994 May 24;91(11):5109–5113. doi: 10.1073/pnas.91.11.5109

Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.

W W Cruikshank 1, D M Center 1, N Nisar 1, M Wu 1, B Natke 1, A C Theodore 1, H Kornfeld 1
PMCID: PMC43941  PMID: 7910967

Abstract

Lymphocyte chemoattractant factor (LCF) is a lymphocyte cell product that stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. In concert with its chemoattractant activity, LCF induces human T-lymphocyte expression of interleukin 2 receptor. Here we describe the molecular cloning of cDNA encoding human LCF. It is a novel interleukin with no significant homology to any previously described cytokine families. There is an absolute requirement for both autoaggregation of LCF monomers and for membrane-expressed CD4 molecules for LCF-induced migration in lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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