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. 1994 Jun 7;91(12):5325–5329. doi: 10.1073/pnas.91.12.5325

BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth.

T Kaisho 1, J Ishikawa 1, K Oritani 1, J Inazawa 1, H Tomizawa 1, O Muraoka 1, T Ochi 1, T Hirano 1
PMCID: PMC43987  PMID: 8202488

Abstract

Bone marrow stromal cells are essential for B-lymphocyte development. However, how stromal cells regulate B lymphopoiesis is not clear. In this paper, we report the molecular cloning of a stromal cell line-derived glycosyl-phosphatidylinositol-anchored molecule, BST-1, that facilitates pre-B-cell growth. The deduced amino acid sequence of BST-1 exhibited 33% identity with CD38. BST-1 was expressed in a wide range of tissues and in umbilical vein endothelial cells, whereas it was scarcely expressed in a variety of hematopoietic cell lines. The gene for BST-1 was assigned to chromosome 14q32.3, where immunoglobulin heavy-chain genes are clustered. BST-1 expression was enhanced in rheumatoid arthritis patient-derived bone marrow stromal cell lines that were previously shown to have an enhanced ability to support the growth of a pre-B-cell line as compared with stromal cell lines derived from healthy donors.

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