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. 1980 Feb;65(2):184–185. doi: 10.1104/pp.65.2.184

Crown Gall Tumor Disc Bioassay

A POSSIBLE AID IN THE DETECTION OF COMPOUNDS WITH ANTITUMOR ACTIVITY

Alan G Galsky 1,2,1, James P Wilsey 1,2, Richard G Powell 1,2
PMCID: PMC440294  PMID: 16661157

Abstract

Seventeen samples consisting of purified compounds and various ethanol extracts from plant sources were tested for activity on the initiation of crown gall tumors on potato discs. The results demonstrated definite correlation between the ability of these samples to inhibit the formation of crown gall tumors and their activity on the P388 leukemia system in mice. Samples showing only cytotoxic effects in KB cell cultures did not affect tumor initiation in our system. The active materials had no effects on bacterial viability or on the ability of the bacteria to attach to a tumorbinding site.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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