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. Author manuscript; available in PMC: 2016 Jun 4.
Published in final edited form as: Neuroscience. 2015 Mar 20;295:58–71. doi: 10.1016/j.neuroscience.2015.03.025

Figure 6.

Figure 6

Mean (± s.e.m) difference scores (post-injection minus pre-injection) for horizontal (top) and vertical activity (bottom) induced by d-amphetamine (1.0 mg/kg, i.p.) or saline vehicle during the treatment (left) and challenge (right) phases of d-amphetamine-induced hyperactivity testing. During treatment, separate groups of ad libitum fed (AL) and food-restricted (FR) rats (n=8) were injected with d-amphetamine or saline every 48-72 hours. Activity was recorded in response to the first and fifth injections, with intervening injections administered in the home cage. The test phase was initiated 3 weeks after all FR rats had been returned to AL feeding. D-amphetamine was injected once per week for 3 consecutive weeks and activity measures were taken in the two former FR groups and the two groups that had been AL throughout (see text for statistical analyses).