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. Author manuscript; available in PMC: 2015 Apr 24.
Published in final edited form as: Science. 2014 Sep 12;345(6202):1292–1294. doi: 10.1126/science.1254166

Figure 1.

Figure 1

A mathematical model of cholera transmission was used to estimate the effectiveness (number of cases averted) and cost-effectiveness in disability averted life years (DALYs) when a given fraction of the population is vaccinated. The model predicts that the fraction of cases averted by mass vaccination (black solid line) exceeds the estimates when only direct protection is assumed (red dashed line). The black dots indicate levels of protection observed in a cholera vaccine trial [21]. In addition, the relationship between vaccine coverage and effectiveness is not linear when assuming overall protection, unlike direct protection [7].