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. 2015 Feb 27;6(6):3947–3962. doi: 10.18632/oncotarget.2968

Figure 5. Knockdown of NDUFAF1 causes mitochondrial dysfunction.

Figure 5

(A) Inhibition of mitochondrial respiratory chain complex I activity by knockdown of NDUFAF1. Data are shown as mean ± SD, *P < 0.05. Western blot analysis showing knockdown efficiency of NDUFAF1. Non-targeting control siRNA (Scram) was used as control. (B) Decrease of oxygen consumption rate after knockdown of NDUFAF1. (C) Decrease of ATP production after NDUFAF1 knockdown, *P < 0.05. (D) Detection of ROS level before and after knockdown of NDUFAF1 by flow cytometry using CM-DCFDA.