Table 2.
Status at randomization
| Placebo n = 3 | PGE 1 n = 4 | |
|---|---|---|
| Primary diagnosis (n) | ||
| Idiopathic | 2 | 0 |
| Aspiration syndrome | 1 | 4 |
| Age at start of INO (hours) mean, (SD) | 26.6 (2.1)a | 7.9 (9.4) |
| Duration of INO before study aerosol (hours) mean, (SD) | 8.0 (6.0)a | 13.4 (7.2) |
| Interval between first OI ≥15 and study aerosol (hours) mean, (SD) | 4.2 (1.2) | 12.2 (5.6) |
| Interval between first and second qualifying blood gases (hours) mean, (SD) | 2.4 (1.2) | 4.7 (3.0) |
| Interval from randomization to study gas initiation (hours) mean, (SD) | 1.2 (0.08) | 2.3 (0.5) |
| Age at randomization (hours) mean, (SD) | 41.7 (15.4) | 19.0 (8.2) |
| OI on baseline ABG mean, (SD) | 26.0 (9.5) | 23.8 (17.3) |
| Therapies prior to randomization (n): | ||
| Volume support | 3 | 4 |
| Vasopressor support | 3 | 3 |
| Sedation or analgesia | 3 | 4 |
| Neuromuscular blockade | 2 | 3 |
| Alkalosis | 2 | 1 |
| Surfactant | 3 | 2 |
aData missing for one subject. ABG, arterial blood gas; INO, inhaled nitric oxide; OI, oxygenation index.