Figure 4.

Integrated networks based on methylation and expression data obtained in SMZL cell lines treated with decitabine. Network integrating both genome-wide DNA methylation profiling (A) and GEP (B) changes after decitabine treatment for 72 hours in the 3 SMZL cell lines (Karpas1718, VL51, and SSK41). (C) Markov cluster algorithm (MCL) clustering identified 5 clusters that were annotated using the wordcloud plugin on Cytoscape (D). Genes highlighted in green were high-methylated and repressed, whereas those in red were low-methylated and upregulated in High-M. Red and blue represent high- and low-level methylation (A), respectively, and red and green represent high- and low-level gene expression (B), respectively.