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. 1957 May;36(5):648–655. doi: 10.1172/JCI103465

APPARENT INHIBITION OF LIVER INSULINASE ACTIVITY BY SERUM AND SERUM FRACTIONS CONTAINING INSULIN-BINDING ANTIBODY

Rosalyn S Yalow 1, Solomon A Berson 1
PMCID: PMC441732  PMID: 13428853

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERSON S. A., YALOW R. S., BAUMAN A., ROTHSCHILD M. A., NEWERLY K. Insulin-I131 metabolism in human subjects: demonstration of insulin binding globulin in the circulation of insulin treated subjects. J Clin Invest. 1956 Feb;35(2):170–190. doi: 10.1172/JCI103262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BERSON S. A., YALOW R. S. Ethanol fractionation of plasma and electrophoretic identification of insulin-binding antibody. J Clin Invest. 1957 May;36(5):642–647. doi: 10.1172/JCI103464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BERSON S. A., YALOW R. S., VOLK B. W. In vivo and in vitro metabolism of insulin-I 131 and glucagon-I 131 in normal and cortisone-treated rabbits. J Lab Clin Med. 1957 Mar;49(3):331–342. [PubMed] [Google Scholar]
  4. COLWELL A. R., WEIGER R. W. Inhibition of insulin action by serum gamma globulin. J Lab Clin Med. 1956 Jun;47(6):844–861. [PubMed] [Google Scholar]
  5. DE FILIPPIS V., IANNACCONE A. Insulin-neutralizing activity of gamma-globulins derived from the serum of an insulin-resistant patient. Lancet. 1952 Jun 14;1(6720):1192–1193. doi: 10.1016/s0140-6736(52)91091-x. [DOI] [PubMed] [Google Scholar]
  6. FERREBEE J. W., JOHNSON B. B., MITHOEFER J. C., GARDELLA J. W. Insulin and adrenocorticotropin labelled with radio-iodine. Endocrinology. 1951 Mar;48(3):277–283. doi: 10.1210/endo-48-3-277. [DOI] [PubMed] [Google Scholar]
  7. LEVER W. F., GURD F. R. N., UROMA E., BROWN R. K., BARNES B. A., SCHMID K., SCHULTZ E. L. Chemical, clinical and immunological studies on the products of human plasma fractionation XL. Quantitative separation and determination of the protein components in small amounts of normal human plasma. J Clin Invest. 1951 Jan;30(1):99–111. doi: 10.1172/JCI102423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LOVELESS M., CANN J. R. Distribution of blocking antibody in human serum proteins fractionated by electrophoresis-convection. J Immunol. 1955 May;74(5):329–339. [PubMed] [Google Scholar]
  9. MIRSKY I. A., PERISUTTI G., DIXON F. J. The destruction of I131-labeled insulin by rat liver extracts. J Biol Chem. 1955 May;214(1):397–408. [PubMed] [Google Scholar]
  10. SEHON A. H., KAYE M., McGARRY E., ROSE B. Localization of an insulin-neutralizing factor by zone electrophoresis in a serum of an insulin-resistant patient. J Lab Clin Med. 1955 May;45(5):765–770. [PubMed] [Google Scholar]
  11. WILLIAMS R. H. Insulin distribution and degradation. Metabolism. 1956 Mar;5(2):128–137. [PubMed] [Google Scholar]

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