Table 2.
Factors Associated with % Annual Change in BMD (g/cm2) in the Menopause Study Cohort
| Total Hip (p; 95% CI) | Femoral Neck (p; 95% CI) | Lumbar Spine (p; 95% CI) | |
|---|---|---|---|
| Black race*HIV | 1.00 (0.0070; 0.27, 1.72) | 1.30 (0.0032; 0.44, 2.16) | 0.43 (0.40; −0.58, 1.45) |
| Black race | −0.42 (0.13; −0.96, 0.12) | −0.72 (0.032; −1.37, −0.064) | 0.028 (0.94; −0.74, 0.80) |
| HIV+ serostatus | −0.46 (0.080; −0.98, 0.054) | −0.49 (0.12; −1.10, 0.13) | −0.59 (0.11; −1.31, 0.13) |
| BMI (kg/m2) | 0.044 (0.0026; 0.015, 0.073) | 0.035 (0.040; 0.0016, 0.069) | 0.096 (<0.0001; 0.058, 0.13) |
| Menopause status (time 1 & 2) | |||
| Pre-menopausal (1) Pre-menopausal (2) |
Reference | Reference | Reference |
| Pre-menopausal (1) Peri-menopausal (2) |
−0.64 (0.024; −1.19, −0.086) | −0.68 (0.043; −1.34, −0.023) | −0.68 (0.085; −1.46, 0.095) |
| Peri-menopausal (1) Peri-menopausal (2) |
−0.58 (0.019; −1.055, −0.097) | −0.31 (0.29; −0.88, 0.27) | −0.22 (0.51; −0.90, 0.45) |
| Peri-menopausal (1) Post-menopausal (2) |
−1.68 (<0.0001; −2.43, −0.92) | −0.79 (0.080; −1.68, 0.096) | −0.53 (0.32; −1.57, 0.52) |
| Post-menopausal (1) Post-menopausal (2) |
−1.020 (0.0066; −1.75, −0.29) | −0.49 (0.27; −1.36, 0.38) | −0.53 (0.31; −1.56, 0.49) |
| HCV+ serostatus | −0.19 (0.33; −0.58, 0.20) | −0.56 (0.019; −1.026, −0.095) | −0.21 (0.45; −0.76, 0.34) |
| FSH level (per IU/L) | −0.0079 (0.20; −0.020, 0.0041) | −0.00029 (0.97; −0.014, 0.013) | −0.020 (0.014; −0.036, −0.0042) |
Abbreviations: BMD: bone mineral density; CI: confidence interval; HIV: human immunodeficiency virus; BMI: body mass index. Models are adjusted for baseline BMD, age, race, BMI, menopause status at time 1 and 2 (reference value is premenopausal at time 1 and 2), smoking pack years, methadone use, HIV status, HCV status, FSH level, 25OH vitamin D