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. 1964 Nov;43(11):2037–2047. doi: 10.1172/JCI105078

Prolonged Neonatal Unconjugated Hyperbilirubinemia Associated with Breast Feeding and a Steroid, Pregnane-3 (Alpha), 20 (Beta)-Diol, in Maternal Milk That Inhibits Glucuronide Formation In Vitro*

Irwin M Arias 1,2,3,4, Lawrence M Gartner 1,2,3,4,†, Sam Seifter 1,2,3,4, Mathilda Furman 1,2,3,4
PMCID: PMC441992  PMID: 14228539

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARIAS I. M. The chemical basis of kernicterus. Adv Clin Chem. 1960;3:35–82. doi: 10.1016/s0065-2423(08)60098-0. [DOI] [PubMed] [Google Scholar]
  2. AXELROD J., SCHMID R., HAMMAKER L. A biochemical lesion in congenital, nonobstructive, non-haemolytic jaundice. Nature. 1957 Dec 21;180(4599):1426–1427. doi: 10.1038/1801426a0. [DOI] [PubMed] [Google Scholar]
  3. BRADSHAW T. E., JESSOP W. J. The urinary excretion of oestrogens and pregnanediol at the end of pregnancy, during labour and during the early puerperium. J Endocrinol. 1953 Oct;9(4):427–439. doi: 10.1677/joe.0.0090427. [DOI] [PubMed] [Google Scholar]
  4. BROWN A. K., ZUELZER W. W. Studies on the neonatal development of the glucuronide conjugating system. J Clin Invest. 1958 Mar;37(3):332–340. doi: 10.1172/JCI103613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CRIGLER J. F., Jr, NAJJAR V. A. Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics. 1952 Aug;10(2):169–180. [PubMed] [Google Scholar]
  6. GARTNER L. M., ARIAS I. M. DEVELOPMENTAL PATTERN OF GLUCURONIDE FORMATION IN RAT AND GUINEA PIG LIVER. Am J Physiol. 1963 Oct;205:663–666. doi: 10.1152/ajplegacy.1963.205.4.663. [DOI] [PubMed] [Google Scholar]
  7. HOLTON J. B., LATHE G. H. INHIBITORS OF BILIRUBIN CONJUGATION IN NEW-BORN INFANT SERUM AND MALE URINE. Clin Sci. 1963 Dec;25:499–509. [PubMed] [Google Scholar]
  8. HSIA D. Y., DOWBEN R. M., SHAW R., GROSSMAN A. Inhibition of glucuronosyl transferase by progestational agents from serum of pregnant women. Nature. 1960 Aug 20;187:693–694. doi: 10.1038/187693a0. [DOI] [PubMed] [Google Scholar]
  9. HSIA D. Y., RIABOV S., DOWBEN R. M. INHIBITION OF GLUCURONOSYL TRANSFERASE BY STEROID HORMONES. Arch Biochem Biophys. 1963 Nov;103:181–185. doi: 10.1016/0003-9861(63)90392-8. [DOI] [PubMed] [Google Scholar]
  10. LATHE G. H., WALKER M. Inhibition of bilirubin conjugation in rat liver slices by human pregnancy and neonatal serum and steroids. Q J Exp Physiol Cogn Med Sci. 1958 Jul;43(3):257–265. doi: 10.1113/expphysiol.1958.sp001328. [DOI] [PubMed] [Google Scholar]
  11. Levvy G. A., Storey I. D. The measurement of glucuronide synthesis by tissue preparations. Biochem J. 1949;44(3):295–299. doi: 10.1042/bj0440295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. NEWMAN A. J., GROSS S. HYPERBILIRUBINEMIA IN BREAST-FED INFANTS. Pediatrics. 1963 Dec;32:995–1001. [PubMed] [Google Scholar]
  13. SCHMID R. The identification of direct-reacting bilirubin as bilirubin glucuronide. J Biol Chem. 1957 Dec;229(2):881–888. [PubMed] [Google Scholar]

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