Abstract
Epinephrine stimulated lipolysis and the uptake of oxygen by subcutaneous adipose cells of man. When glucose-14C was present in the medium, its utilization was not increased by epinephrine, although lipolysis was accelerated. Insulin did not reduce the production of fatty acids that had been stimulated by epinephrine.
The combination of human growth hormone and cortisol stimulated the production of fatty acids by isolated human adipose cells to a lesser extent than epinephrine. When human growth hormone or cortisol was used singly, or when bovine growth hormone was added in combination with cortisol, no effect on fatty acid production was observed. Furthermore, an acetone-dried preparation of human pituitary glands, which was shown to stimulate lipolysis in rat adipose cells, had no effect on fatty acid formation in human adipose cells. This suggested that the human pituitary gland contained no more potent lipolytic agents than growth hormone and was supported by the lack of response of human adipose cells to purified corticotropin.
Full text
PDF








Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BALL E. G., JUNGAS R. L. On the action of hormones which accelerate the rate of oxygen consumption and fatty acid release in rat adipose tissue in vitro. Proc Natl Acad Sci U S A. 1961 Jul 15;47:932–941. doi: 10.1073/pnas.47.7.932. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BJOERNTORP P. THE FATTY ACID RELEASE AND LIPOLYSIS OF HUMAN SUBCUTANEOUS ADIPOSE TISSUE IN VITRO. Metabolism. 1964 Nov;13:1318–1326. doi: 10.1016/0026-0495(64)90151-9. [DOI] [PubMed] [Google Scholar]
- Burns T. W., Hales C. N. Regulation of lipolysis in isolated human adipose-tissue cells. Lancet. 1966 Apr 9;1(7441):796–798. doi: 10.1016/s0140-6736(66)91868-x. [DOI] [PubMed] [Google Scholar]
- DOLE V. P. A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J Clin Invest. 1956 Feb;35(2):150–154. doi: 10.1172/JCI103259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DOLE V. P., MEINERTZ H. Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem. 1960 Sep;235:2595–2599. [PubMed] [Google Scholar]
- FRITZ I. B. Factors influencing the rates of long-chain fatty acid oxidation and synthesis in mammalian systems. Physiol Rev. 1961 Jan;41:52–129. doi: 10.1152/physrev.1961.41.1.52. [DOI] [PubMed] [Google Scholar]
- Fain J. N., Kovacev V. P., Scow R. O. Effect of growth hormone and dexamethasone on lipolysis and metabolism in isolated fat cells of the rat. J Biol Chem. 1965 Sep;240(9):3522–3529. [PubMed] [Google Scholar]
- Galton D. Studies on the respiratory metabolism of isolated human adipose cells. Biochem J. 1966 Oct;101(1):164–168. doi: 10.1042/bj1010164. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAMOSH M., HAMOSH P., BAR-MAOR J. A., COHEN H. FATTY-ACID METABOLISM BY HUMAN ADIPOSE TISSUES. J Clin Invest. 1963 Oct;42:1648–1652. doi: 10.1172/JCI104850. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mosinger B., Kuhn E., Kujalová V. Action of adipokinetic hormones on human adipose tissue in vitro. J Lab Clin Med. 1965 Sep;66(3):380–389. [PubMed] [Google Scholar]
- RABEN M. S., HOLLENBERG C. H. Effect of growth hormone on plasma fatty acids. J Clin Invest. 1959 Mar;38(3):484–488. doi: 10.1172/JCI103824. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RODBELL M. METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. J Biol Chem. 1964 Feb;239:375–380. [PubMed] [Google Scholar]