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. 1967 Apr;46(4):659–667. doi: 10.1172/JCI105567

The Influence of Amino Acids on Copper Uptake by Rat Liver Slices *

Daisy I M Harris 1,2,, Andrew Sass-Kortsak 1,2,
PMCID: PMC442049  PMID: 6021212

Abstract

Addition of physiological concentrations of 20 l-amino acids to the incubation medium facilitates the uptake of copper by liver slices. This effect can be observed in a wide range of initial concentrations of copper in the medium, including the low physiological concentrations. The uptake of copper was not influenced by the addition of sodium lactate or d-glucose to the incubation media. The facilitation of copper uptake by amino acids is abolished under anaerobic conditions. It is not affected by the presence of 2,4-dinitrophenol. The type of transport and its exact mechanism have not been established, but this type of transport does not fulfill the criteria for classification as simple diffusion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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