Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1971 Aug;50(8):1585–1595. doi: 10.1172/JCI106646

The Regulation of Aldosterone Secretion in Anephric Man

Francis Bayard 1,2,3, C Robert Cooke 1,2,3, David J Tiller 1,2,3, Inese Z Beitins 1,2,3, Avinoam Kowarski 1,2,3, W Gordon Walker 1,2,3, Claude J Migeon 1,2,3
PMCID: PMC442057  PMID: 4329001

Abstract

The regulation of aldosterone secretion in anephric man was investigated in studies on nephrectomized patients who were being intermittently hemodialyzed while awaiting renal transplantation. The effects of supine and upright posture on the concentration of plasma aldosterone on the 1st day postdialysis and on a 3rd or 4th day postdialysis were compared to the effects of postural variation in normal subjects who were on a low sodium intake and on a high sodium intake. In contrast with the normal subjects who exhibited higher concentrations of plasma aldosterone after 2 hr of upright posture than in the supine position and low concentrations of plasma aldosterone on a high sodium intake, the anephric patients showed less consistent variations in plasma aldosterone due to changes in posture and exhibited higher concentrations of plasma aldosterone on the 3rd or 4th day postdialysis, despite an increase in body weight, than on the 1st day postdialysis.

The increase in the concentration of plasma aldosterone in the anephric patients between the 1st day postdialysis and the 3rd or 4th day postdialysis indicates that aldosterone secretion is not responding primarily, in this situation, to volume-related stimuli. There was a high degree of correlation between the concentration of plasma aldosterone and the corresponding levels of serum potassium concentration, which also rose significantly between the 1st day postdialysis and the 3rd or 4th day postdialysis. Furthermore, when potassium accumulation between dialyses was prevented in three of these patients, the concentration of plasma aldosterone fell to minimally detectable levels. The results of these studies suggest that the primary regulator of aldosterone secretion in the absence of the kidneys is potassium.

Full text

PDF
1585

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTTER F. C., DUNCAN L. E., Jr, LIDDLE G. W. Dual mechanism regulating adrenocortical function in man. Am J Med. 1956 Sep;21(3):380–386. doi: 10.1016/0002-9343(56)90038-9. [DOI] [PubMed] [Google Scholar]
  2. BLAIR WEST J. R., COGHLAN J. P., DENTON D. A., GODING J. R., WINTOUR M., WRIGHT R. D. THE CONTROL OF ALDOSTERONE SECRETION. Recent Prog Horm Res. 1963;19:311–383. [PubMed] [Google Scholar]
  3. Balikian H. M., Brodie A. H., Dale S. L., Melby J. C., Tait J. F. Effect of posture on the metabolic clearance rate, plasma concentration and blood production rate of aldosterone in man. J Clin Endocrinol Metab. 1968 Nov;28(11):1630–1640. doi: 10.1210/jcem-28-11-1630. [DOI] [PubMed] [Google Scholar]
  4. Bayard F., Ances I. G., Tapper A. J., Weldon V. V., Kowarski A., Migeon C. J. Transplacental passage and fetal secretion of aldosterone. J Clin Invest. 1970 Jul;49(7):1389–1393. doi: 10.1172/JCI106356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bayard F., Beitins I. Z., Kowarski A., Migeon C. J. Measurement of plasma aldosterone by radioimmunoassay. J Clin Endocrinol Metab. 1970 Jul;31(1):1–6. doi: 10.1210/jcem-31-1-1. [DOI] [PubMed] [Google Scholar]
  6. Bayard F., Kowarski A., Weldon V. V., Migeon C. J. Appraisal of the double isotope dilution techniques for the measurement of plasma aldosterone. J Lab Clin Med. 1970 Feb;75(2):347–354. [PubMed] [Google Scholar]
  7. Beitins I. Z., Shaw M. H., Kowarski A., Migeon C. J. Comparison of competitive protein binding radioassay of cortisol to double isotope dilution and Porter Silber methods. Steroids. 1970 Jun;15(6):765–776. doi: 10.1016/s0039-128x(70)80045-9. [DOI] [PubMed] [Google Scholar]
  8. Bledsoe T., Island D. P., Liddle G. W. Studies of the mechanism through which sodium depletion increases aldosterone biosynthesis in man. J Clin Invest. 1966 Apr;45(4):524–530. doi: 10.1172/JCI105366. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Brodie A. H., Shimizu N., Tait S. A., Tait J. F. A method for the measurement of aldosterone in peripheral plasma using 3H-acetic anhydride. J Clin Endocrinol Metab. 1967 Jul;27(7):997–1011. doi: 10.1210/jcem-27-7-997. [DOI] [PubMed] [Google Scholar]
  10. CEJKA V., de VRIES L., van DAATSELAAR J., BORST J. G., MAJOOR C. L. Effect of heparinoid and spirolactone on the renal excretion of sodium and aldosterone. Lancet. 1960 Feb 6;1(7119):317–319. doi: 10.1016/s0140-6736(60)90242-7. [DOI] [PubMed] [Google Scholar]
  11. Cannon P. J., Ames R. P., Laragh J. H. Relation between potassium balance and aldosterone secretion in normal subjects and in patients with hypertensive or renal tubular disease. J Clin Invest. 1966 Jun;45(6):865–879. doi: 10.1172/JCI105402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Capelli J. P., Wesson L. G., Jr, Aponte G. E., Faraldo C., Jaffe E. Characterization and source of a renin-like enzyme in anephric humans. J Clin Endocrinol Metab. 1968 Feb;28(2):221–230. doi: 10.1210/jcem-28-2-221. [DOI] [PubMed] [Google Scholar]
  13. Coghlan J. P., Scoggins B. A. Measurement of aldosterone in peripheral blood of man and sheep. J Clin Endocrinol Metab. 1967 Oct;27(10):1470–1486. doi: 10.1210/jcem-27-10-1470. [DOI] [PubMed] [Google Scholar]
  14. Cohen E. L., Conn J. W., Rovner D. R. Postural augmentation of plasma renin activity and aldosterone excretion in normal people. J Clin Invest. 1967 Mar;46(3):418–428. doi: 10.1172/JCI105543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. DAVIS J. O., AYERS C. R., CARPENTER C. C. Renal origin of an aldosterone-stimulating hormone in dogs with thoracic caval constriction and in sodium-depleted dogs. J Clin Invest. 1961 Aug;40:1466–1474. doi: 10.1172/JCI104377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. DAVIS J. O., CARPENTER C. C., AYERS C. R., HOLMAN J. E., BAHN R. C. Evidence for secretion of an aldosterone-stimulating hormone by the kidney. J Clin Invest. 1961 Apr;40:684–696. doi: 10.1172/JCI104301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. DAVIS J. O., URQUHART J., HIGGINS J. T., Jr The effects of alteration of plasma sodium and potassium concentration on aldosterone secretion. J Clin Invest. 1963 May;42:597–609. doi: 10.1172/JCI104750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. GANN D. S., DELEA C. S., GILL J. R., Jr, THOMAS J. P., BARTTER F. C. CONTROL OF ALDOSTERONE SECRETION BY CHANGE OF BODY POTASSIUM IN NORMAL MAN. Am J Physiol. 1964 Jul;207:104–108. doi: 10.1152/ajplegacy.1964.207.1.104. [DOI] [PubMed] [Google Scholar]
  19. Ganong W. F., Biglieri E. G., Mulrow P. J. Mechanisms regulating adrenocortical secretion of aldosterone and glucocorticoids. Recent Prog Horm Res. 1966;22:381–430. doi: 10.1016/b978-1-4831-9825-5.50013-0. [DOI] [PubMed] [Google Scholar]
  20. HELMER O. M. Presence of renin in plasma of patients with arterial hypertension. Circulation. 1962 Jan;25:169–173. doi: 10.1161/01.cir.25.1.169. [DOI] [PubMed] [Google Scholar]
  21. HIGGINS J. T., Jr, DAVIS J. O., URQUHART J., OLICHNEY M. J. INCREASED PLASMA LEVEL OF RENIN IN EXPERIMENTAL SECONDARY HYPERALDOSTERONISM. Am J Physiol. 1964 Oct;207:814–820. doi: 10.1152/ajplegacy.1964.207.4.814. [DOI] [PubMed] [Google Scholar]
  22. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  23. LARAGH J. H., STOERK H. C. A study of the mechanism of secretion of the sodium-retaining hormone (aldosterone). J Clin Invest. 1957 Mar;36(3):383–392. doi: 10.1172/JCI103434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. MORAN W. H., Jr, ROSENBERG J. C., ZIMMERMANN B. The regulation of aldosterone output: significance of potassium ion. Surg Forum. 1958;9:120–122. [PubMed] [Google Scholar]
  25. McKenzie J. K., Montgomerie J. Z. Renin-like activity in the plasma of anephric men. Nature. 1969 Sep 13;223(5211):1156–1156. doi: 10.1038/2231156a0. [DOI] [PubMed] [Google Scholar]
  26. SCHLATMANN R. J., JANSEN A. P., PRENEN H., VAN DER KORST J. K., MAJOOR C. L. THE NATRIURETIC AND ALDOSTERONE-SUPPRESSIVE ACTION OF HEPARIN AND SOME RELATED POLYSULFATED POLYSACCHARIDES. J Clin Endocrinol Metab. 1964 Jan;24:35–47. doi: 10.1210/jcem-24-1-35. [DOI] [PubMed] [Google Scholar]
  27. TAIT J. F., LITTLE B., TAIT S. A., FLOOD C. The metabolic clearance rate of aldosterone in pregnant and nonpregnant subjects estimated by both single-injection and constant-infusion methods. J Clin Invest. 1962 Dec;41:2093–2100. doi: 10.1172/JCI104667. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES