Table 5.

Growth inhibition of various cell lines after 3 h treatment with the gold(III) compounds 1 and 2.

	IC50[a] [μM]
Cmpd	SAOS-2	HeLa	HCT116	MEF NF1−/−
1	12.2±1.6	17.7±1.6	15.8±2.1	3.6±0.9
2	26.4±3.1	30.8±4.2	43.6±5.4	7.8±1.1
Cisplatin	NE[b]	NE[b]	NE[b]	NE[b]

[a] Data represent the mean ± S.D. for n=7. Cells tested were the following: human tumor cell lines SAOS-2 (human osteosarcoma), HeLa (cervical cancer), and HCT116 (colon neoplasia) and the immortalized primary mouse embryonic fibroblast (MEF) model MEF-NF1^−/− (isolated from knockout strains for the oncosuppressor gene neurofibromine); [b] NE stands for not evaluable at 3 h treatment.